Registration Dossier
Registration Dossier
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EC number: 214-987-2 | CAS number: 1241-94-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed similar to OECD guideline 404, not under GLP, but acceptable basic data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexyl diphenyl phosphate
- EC Number:
- 214-987-2
- EC Name:
- 2-ethylhexyl diphenyl phosphate
- Cas Number:
- 1241-94-7
- Molecular formula:
- C20H27O4P
- IUPAC Name:
- 2-ethylhexyl diphenyl phosphate
- Details on test material:
- - Name of test material (as cited in study report): 2-ethylhexyl diphenyl phosphate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data
- Duration of treatment / exposure:
- No data
- Observation period:
- No data
- Number of animals:
- 3
- Details on study design:
- No data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- other: scoring method not provided
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hr
- Score:
- 1.3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: scoring method not provided
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hr
- Score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: scoring method not available
- Remarks:
- results per animals not available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hr
- Score:
- 2.3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: scoring method not provided
- Remarks:
- results per animals not available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 5 days
- Score:
- 0.6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: scoring method not provided
- Remarks:
- results per animals not available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 0
- Reversibility:
- other: not applicable
- Remarks on result:
- other: scoring method not provided
- Remarks:
- results per animals not available
- Irritant / corrosive response data:
- Slightly irritating to rabbit skin
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The reaction of the test material, 2-ethylhexyl diphenyl phosphate, on the skin was reported as slightly irritating. Given the report that only slight irritation was observed for both skin and eye, it is considered that the irritant potential of 2-ethylhexyl diphenyl phosphate may be low and, therefore, in addition, it is considered unlikely that 2-ethylhexyl diphenyl phosphate possesses any corrosive properties.
- Executive summary:
In this GLP non-compliant study of skin irritation, three rabbits (strain and sex not reported) were given dermal applications of the test material 2-ethylhexyl diphenyl phosphate. The reaction was reported as slightly irritating. Given the report that only slight irritation was observed for both skin and eye, it is considered that the irritant potential of 2-ethylhexyl diphenyl phosphate may be low and, therefore, in addition, it is considered unlikely that 2-ethylhexyl diphenyl phosphate possesses any corrosive properties.
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