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EC number: 205-528-7 | CAS number: 142-22-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 1979 - March 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Equivalent to guideline study; the study passed a Quality Assurance audit (dated 1981-03-24)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Diallyl 2,2'-oxydiethyl dicarbonate
- EC Number:
- 205-528-7
- EC Name:
- Diallyl 2,2'-oxydiethyl dicarbonate
- Cas Number:
- 142-22-3
- Molecular formula:
- C12H18O7
- IUPAC Name:
- 3-({[2-(2-{[(prop-2-en-1-yloxy)carbonyl]oxy}ethoxy)ethoxy]carbonyl}oxy)prop-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 100% DDC (Diallyl Diglycol Carbonate)
- Substance type: organic
- Physical state: clear, colorless liquid
- Analytical purity: data not available
- Impurities (identity and concentrations): data not available
- Composition of test material, percentage of components:
- Isomers composition: data not available
- Purity test date: data not available
- Lot/batch No.: data not available
- Expiration date of the lot/batch: data not available
- Stability under test conditions: data not available
- Storage condition of test material: at room temperature in a locked test compound cabinet.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the left eye served as the untreated control
- Duration of treatment / exposure:
- a single exposure in one eye of albino rabbits
- Observation period (in vivo):
- All animals were observed closely for gross signs of systemic toxicity and mortality at frequent intervals during the day of dosing and at least twice daily thereafter for a ( total of 14 days. Room conditions as well as availability of adequate food and water were checked and any noteworthy conditions recorded.
- Number of animals or in vitro replicates:
- A total of nine rabbits (6 not rinsed and 3 rinsed) were used.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of six animals
- Time point:
- other: 1 h
- Score:
- 8
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: not rinsed
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- of three animals
- Time point:
- other: 1 h
- Score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: rinsed
- Irritation parameter:
- chemosis score
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Reversibility:
- fully reversible within: 48 h
- Other effects:
- no
Any other information on results incl. tables
Body Weights
Body weights at the termination of the study ranged from 2.15 to 2.75 kilograms. Body weight changes appear to be normal.
Observations and Mortality
No animal exhibited signs of systemic toxicity and no deaths occurred during the investigation.
Necropsy
Evaluation of the test animals at necropsy by the pathologist revealed no significant gross pathologic findings.
Primary Eye Irritation Index
Means of individual irritation scores used to calculate the primary irritation index presented in Table 3 and 4.
Table 3: Primary Eye Irritation Index in Rabbits (not rinsed)
Tissue |
Examination Intervals |
||||||
1 h |
6 h |
24 h |
48 h |
72 h |
4 Days |
7 Days |
|
Cornea |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Conjunctiva |
48 |
4 |
0 |
0 |
0 |
0 |
0 |
Total |
48 |
4 |
0 |
0 |
0 |
0 |
0 |
Mean |
8.0 |
0.67 |
0 |
0 |
0 |
0 |
0 |
Table 4: Primary Eye Irritation Index in Rabbits (rinsed)
Tissue |
Examination Intervals |
||||||
1 h |
6 h |
24 h |
48 h |
72 h |
4 Days |
7 Days |
|
Cornea |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Conjunctiva |
18 |
4 |
2 |
0 |
0 |
0 |
0 |
Total |
18 |
4 |
2 |
0 |
0 |
0 |
0 |
Mean |
3.0 |
0.67 |
0.33 |
0 |
0 |
0 |
0 |
Positive scores only noted in the conjunctiva lasted through the 24-hour examination interval. No positive findings were noted upon further examination with fluorescein dye.
Applicant's summary and conclusion
- Interpretation of results:
- other: EU GHS criteria not met
- Conclusions:
- According method of Draize, when 100% DDC (diallyl diglycol carbonate) was instilled into one eye of each of nine albino rabbits (6 not rinsed and 3 rinsed) the primary eye irritation index was determined to be 8.0 and was classified as minimally irritating. Instillation of water into the treated eyes of three rabbits did not change the classification but decreased the score to 3.0. According to the guidance to Regulation (EC) No 1272/2008 (CLP Regulation) [ECHA Guidance on the Application of the CLP Criteria, Aug 2009; p. 249], Diallyl Diglycol Carbonate does not meet criteria for classification as eye irritant.
- Executive summary:
The objective of this study was to determine the irritative potential of the test material following a single exposure in one eye of albino rabbits. Nine rabbits (6 not rinsed and 3 rinsed) were used.
0.1 mL of undiluted test material was instilled in the right eye of each animal. All animals were observed for signs of systemic toxicity and mortality until sacrifice on day 14. Body weights on the day of exposure and the termination were recorded. A gross necropsy were performed on the visceral and thoracic cavities. Primary Eye Irritation Index was calculated using the standard scoring system of Draize.
No positive findings were noted in two ocular tissues: cornea and iris. Positive scores were only noted in the conjunctiva lasted through 24 -hour interval. The one-hour interval provided the highest mean score (8.0) for 100% DDC (diallyl diglycol carbonate) and was therefore used as the primary irritation index and classified the test compound as minimally irritating using the method of Draize. Instillation of water into the treated eyes of three rabbits did not change the classification but decreased the mean score to 3.0.
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