Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-433-0 | CAS number: 10163-15-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Preliminary studies of the caries inhibiting potential and acute toxicity of sodium monofluorophosphate
- Author:
- Shourie KL, Hein JW & Hodge HC
- Year:
- 1 950
- Bibliographic source:
- J. D. Res. 29():529
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- Principles of method if other than guideline:
- One hundred and five albino rats were given graded doses from 74 mg/ kg to 465 mg/ kg of sodium monoflurophosphate as a 5% aqueous solution. The route of administration was intraperitoneal injection, the number of animals dead in 24 hours was used to calculate the LD50.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Disodium fluorophosphate
- EC Number:
- 233-433-0
- EC Name:
- Disodium fluorophosphate
- Cas Number:
- 10163-15-2
- Molecular formula:
- FH2O3P.2Na
- IUPAC Name:
- disodium fluorophosphate
- Details on test material:
- - Name of test material (as cited in study report): sodium monofluorophosphate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-300 grams
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- no data
- Doses:
- Graded doses from 74 mg/ kg to 465 mg/ kg of sodium monoflurophosphate as a 5% aqueous solution.
- No. of animals per sex per dose:
- 105 rats were divided into 13 groups of five to ten animals.
- Control animals:
- not specified
- Details on study design:
- The number of animals dead within a 24 h observation period were used to calculate the LD50 of the compound
- Statistics:
- From the number of animals dead in 24 h the LD50 was calculated by use of the Winthrop logarithmic-probit graph paper.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 220 mg/kg bw
- Remarks on result:
- other: ± 32 mg/ kg standard error
- Mortality:
- On the basis of Fluoride content alone the LD50 is 29 mg/ kg
- Clinical signs:
- No data.
- Body weight:
- No data.
- Gross pathology:
- No data.
- Other findings:
- No data.
Any other information on results incl. tables
No data.
Applicant's summary and conclusion
- Conclusions:
- The LD50 of sodium monofluorophosphate was 220 ± 32 mg/ kg bodyweight in rats weighing 200 to 300 grams.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.