Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 226-237-1 | CAS number: 5332-24-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
LD50 was estimated to be 2921 mg/kg bw, when Tif: RAIf (SPF) male and female rats were treated with 3-Bromoquinoline orally by intubation.
Acute Dermal toxicity:
LD50 was estimated to be 2957 mg/kg bw, when New Zealand White male and female rabbits were treated with 3-Bromoquinoline by dermal application occlusively.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is predicted using OECD QSAR toolbox version 3.3 and the supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material : 3-Bromoquinoline
- Molecular formula : C9H6BrN
- Molecular weight : 208.057 g/mol
- Smiles notation : c12c(ncc(c1)Br)cccc2
- InChl : 1S/C9H6BrN/c10-8-5-7-3-1-2-4-9(7)11-6-8/h1-6H
- Substance type: Organic
- Physical state: Liquid - Species:
- rat
- Strain:
- other: Tif: RAIf (SPF) strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2921 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Preliminary study:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 921 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was estimated to be 2921 mg/kg bw, when Tif: RAIf (SPF) male and female rats were treated with 3-Bromoquinoline orally by gavage..
- Executive summary:
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 3-Bromoquinoline (5332-24-1). The LD50 was estimated to be 2921 mg/kg bw, when Tif: RAIf (SPF) male and female rats were treated with 3-Bromoquinoline orally by gavage.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(((((((("a"
or "b" or "c" )
and ("d"
and (
not "e")
)
)
and ("f"
and (
not "g")
)
)
and "h" )
and "i" )
and ("j"
and (
not "k")
)
)
and ("l"
and (
not "m")
)
)
and ("n"
and "o" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as SN2 AND SN2 >> Direct acting
epoxides formed after metabolic activation AND SN2 >> Direct acting
epoxides formed after metabolic activation >> Quinoline Derivatives AND
SN2 >> SN2 at an activated carbon atom AND SN2 >> SN2 at an activated
carbon atom >> Quinoline Derivatives by DNA binding by OASIS v.1.3
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Class 2 (less inert compounds)
by Acute aquatic toxicity classification by Verhaar (Modified)
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Halopyrdines by Aquatic toxicity
classification by ECOSAR
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> P450
Mediated Activation to Isocyanates or Isothiocyanates OR Acylation >>
P450 Mediated Activation to Isocyanates or Isothiocyanates >>
Benzylamines-Acylation OR Michael addition OR Michael addition >> P450
Mediated Activation to Quinones and Quinone-type Chemicals OR Michael
addition >> P450 Mediated Activation to Quinones and Quinone-type
Chemicals >> Alkyl phenols OR Michael addition >> P450 Mediated
Activation to Quinones and Quinone-type Chemicals >> Arenes OR Michael
addition >> P450 Mediated Activation to Quinones and Quinone-type
Chemicals >> Hydroquinones OR Schiff base formers OR Schiff base formers
>> Chemicals Activated by P450 to Glyoxal OR Schiff base formers >>
Chemicals Activated by P450 to Glyoxal >> Ethylenediamines (including
piperazine) OR SN1 OR SN1 >> Carbenium Ion Formation OR SN1 >> Carbenium
Ion Formation >> Allyl benzenes OR SN1 >> Iminium Ion Formation OR SN1
>> Iminium Ion Formation >> Aliphatic tertiary amines OR SN1 >>
Nitrenium Ion formation OR SN1 >> Nitrenium Ion formation >> Aromatic
nitro OR SN1 >> Nitrenium Ion formation >> Primary aromatic amine OR SN1
>> Nitrenium Ion formation >> Secondary aromatic amine OR SN1 >>
Nitrenium Ion formation >> Tertiary aromatic amine OR SN2 OR SN2 >>
Direct Acting Epoxides and related OR SN2 >> Direct Acting Epoxides and
related >> Epoxides OR SN2 >> SN2 at an sp3 Carbon atom OR SN2 >> SN2 at
an sp3 Carbon atom >> Aliphatic halides by DNA binding by OECD
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Moderate binder, NH2 group OR
Moderate binder, OH grooup OR Non binder, impaired OH or NH2 group OR
Non binder, MW>500 OR Non binder, non cyclic structure OR Strong binder,
NH2 group OR Strong binder, OH group OR Very strong binder, OH group OR
Weak binder, NH2 group OR Weak binder, OH group by Estrogen Receptor
Binding
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as No superfragment by
Superfragments ONLY
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Not categorized by Repeated dose
(HESS)
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Aliphatic amines (Mucous
membrane irritation) Rank C OR Benzene/ Naphthalene sulfonic acids (Less
susceptible) Rank C OR Thiocarbamates/Sulfides (Hepatotoxicity) No rank
by Repeated dose (HESS)
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Not categorized by US-EPA New
Chemical Categories
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Neutral Organics by US-EPA New
Chemical Categories
Domain
logical expression index: "n"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 2.05
Domain
logical expression index: "o"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 3.38
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 921 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from QSAR Toolbox version 3.3
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is predicted using OECD QSAR toolbox version 3.3 and the supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material : 3-Bromoquinoline
- Molecular formula : C9H6BrN
- Molecular weight : 208.057 g/mol
- Smiles notation : c12c(ncc(c1)Br)cccc2
- InChl : 1S/C9H6BrN/c10-8-5-7-3-1-2-4-9(7)11-6-8/h1-6H
- Substance type: Organic
- Physical state: Liquid - Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- 2957 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Preliminary study:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 957 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed.
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was estimated to be 2957 mg/kg bw, when New Zealand White male and female rabbits were treated with 3-Bromoquinoline by dermal application occlusively.
- Executive summary:
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for 3-Bromoquinoline (5332-24-1). The New Zealand White male and female rabbits were treated with 3-Bromoquinoline2 at a concentration 2957 mg/kg bw for 4 hours by dermal application occlusively. 50% mortality was observed at 2957 mg/kg bw. Therefore, LD50 was estimated to be 2957 mg/kg bw, when New Zealand White male and female rabbits were treated with 3-Bromoquinoline by dermal application occlusively.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(((((((((("a"
or "b" or "c" )
and ("d"
and (
not "e")
)
)
and "f" )
and "g" )
and ("h"
and (
not "i")
)
)
and ("j"
and (
not "k")
)
)
and ("l"
and (
not "m")
)
)
and ("n"
and (
not "o")
)
)
and ("p"
and (
not "q")
)
)
and ("r"
and "s" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as SN2 AND SN2 >> Direct acting
epoxides formed after metabolic activation AND SN2 >> Direct acting
epoxides formed after metabolic activation >> Quinoline Derivatives AND
SN2 >> SN2 at an activated carbon atom AND SN2 >> SN2 at an activated
carbon atom >> Quinoline Derivatives by DNA binding by OASIS v.1.3
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Class 2 (less inert compounds)
by Acute aquatic toxicity classification by Verhaar (Modified)
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Halopyrdines by Aquatic toxicity
classification by ECOSAR
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules by DPRA Cysteine peptide depletion
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as High reactive OR High reactive
>> Activated haloarenes OR Low reactive OR Low reactive >> N-substituted
aromatic amides OR Moderate reactive OR Moderate reactive >> Glycidyl
ether epoxides by DPRA Cysteine peptide depletion
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as High (Class III) by Toxic hazard
classification by Cramer (original) ONLY
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding alerts for Chromosomal aberration by OASIS v1.1
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Michael-type
addition to quinoid structures OR AN2 >> Michael-type addition to
quinoid structures >> Phenols by Protein binding alerts for Chromosomal
aberration by OASIS v1.1
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Aromatic heterocyclic halide AND
Aryl AND Aryl halide AND Fused carbocyclic aromatic AND Fused
heterocyclic aromatic AND Pyridine AND Quinoline/ Isoquinoline by
Organic Functional groups
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Ether by Organic Functional
groups
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Aromatic heterocyclic halide AND
Aryl AND Aryl halide AND Fused carbocyclic aromatic AND Fused
heterocyclic aromatic AND Pyridine AND Quinoline/ Isoquinoline by
Organic Functional groups
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Cycloalkane by Organic
Functional groups
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Aromatic heterocyclic halide AND
Aryl AND Aryl halide AND Fused carbocyclic aromatic AND Fused
heterocyclic aromatic AND Pyridine AND Quinoline/ Isoquinoline by
Organic Functional groups
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Sulfonic acid by Organic
Functional groups
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Aromatic heterocyclic halide AND
Aryl AND Aryl halide AND Fused carbocyclic aromatic AND Fused
heterocyclic aromatic AND Pyridine AND Quinoline/ Isoquinoline by
Organic Functional groups
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Aniline by Organic Functional
groups
Domain
logical expression index: "r"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 1.81
Domain
logical expression index: "s"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.38
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 957 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from QSAR Toolbox version 3.3
Additional information
Acute oral toxicity:
In different studies, 3-Bromoquinoline (CAS no 5332-24-1) has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments in rodents, i.e. most commonly in rats and mice for 3-Bromoquinoline along with the study available on structurally similar read across substance 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2) and 2-Chloro-4-ethylamine-6-isopropylamine-1,3,5-triazine (CAS no: 1912-24-9). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies. The studies are summarized as below –
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 3-Bromoquinoline (5332-24-1). The LD50 was estimated to be 2921 mg/kg bw, when Tif: RAIf (SPF) male and female rats were treated with 3-Bromoquinoline orally by intubation.
In experimental study done on structurally similar read across substance 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2) by U.S. National Library of Medicine (ChemIDplus 2017) and RTECS, the acute oral toxicity study was conducted in rat at the concentration of 3840 mg/kg bw orally. 50% mortality was observed at 3840 mg/kg bw. Therefore, LD50 was considered to be 3840 mg/kg bw, when rat was treated with 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine orally.
In another experimental study supported by Raju Kacham (Encyclopedia of Toxicology (Second Edition), Pages 534–535, 2005), for the structurally similar read across substance 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2), the acute oral toxicity study was conducted in rat at the concentration of 3850 mg/kg bw orally. No mortality was observed at 3850 mg/kg bw. Therefore, LD50 was considered to be >3850 mg/kg bw (3850–7000 mg/kg bw), when rat was treated with 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine orally.
This is further supported by experimental study by Raju Kacham (Encyclopedia of Toxicology (Second Edition), Pages 534–535, 2005), U.S. National Library of Medicine (ChemIDplus) and RTECS,for the structurally similar read across substance 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2), the acute oral toxicity study was conducted in mouse at the concentration of 3840 mg/kg bw orally. 50% mortality was observed at 3180 mg/kg bw. Therefore, LD50 was considered to be 3180 mg/kg bw, when mouse was treated with2-chloro-4,6-bis(isopropylamino)-1,3,5-triazineorally.
In another study summarized by J. W. Hauswirth and L. T. Wetzel (In: Ballantine LG, McFarland JE, Hacke (tt DS, eds. Triazine herbicides: risk assessment. Washington, DC: Oxford University Press; 370–83: 1998), for the structurally similar read across substance 2-Chloro-4-ethylamine-6-isopropylamine-1,3,5-triazine (CAS no: 1912-24-9). The acute oral toxicity study was conducted in rat at the concentration of 3000 mg/kg bw orally. No mortality was observed at 3000mg/kg bw. Therefore, LD50 was considered to be >3000 mg/kg bw, when rat was treated with 2-Chloro-4-ethylamine-6-isopropylamine-1,3,5-triazine orally.
Thus, based on the above studies on 3-Bromoquinoline (CAS no 5332-24-1) and it’s read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 3-Bromoquinoline can be classified as category V of acute oral toxicity.
Acute Dermal toxicity:
In different studies, 3-Bromoquinoline (CAS no 5332-24-1) has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments in rodents, i.e. most commonly in rabbits and rats for 3-Bromoquinoline along with the study available on structurally similar read across substance 1-Chloro-4-nitrobenzene (100-00-5) and 1,1,1-Tris(4-hydroxyphenyl)ethane (CAS no: 27955-94-8). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies. The studies are summarized as below –
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for 3-Bromoquinoline (5332-24-1). The New Zealand White male and female rabbits were treated with 3-Bromoquinoline at a concentration 2957 mg/kg bw for 4 hours by dermal application occlusively. 50% mortality was observed at 2957 mg/kg bw. Therefore, LD50 was estimated to be 2957 mg/kg bw, when New Zealand White male and female rabbits were trated with 3-Bromoquinoline by dermal application occlusively.
In another experimental study supported by U.S. National Library of Medicine (ChemIDplus,2017) and National Toxicology Program (National Toxicology Program Toxicity Report Series Number 33, NIH Publication 93-3382, July 1993), for the structurally similar read across substance 1-Chloro-4-nitrobenzene (100-00-5), the acute dermal toxicity study was done in rabbits at the concentration of 3040 mg/kg bw. 50% mortality was observed at dose 3040 mg/kg bw. Hence, the LD50 value was considered to be 3040 mg/kg bw, when rabbits were treated with 1-Chloro-4-nitrobenzene by dermal application.
This is further supported by U.S. National Library of Medicine (ChemIDplus) and National Technical Reports Library (OTS0530499-1, 1991), for the structurally similar read across substance 1,1,1-Tris(4-hydroxyphenyl)ethane (CAS no: 27955-94-8). The Acute dermal toxicity study was done in rats. A group of 10 CD rats (5 of each sex) was treated with 2000 mg/kg of test material (99% pure Batch No. SN7741, stored in original container in darkness at room temperature) administered as water based slurry. The material was spread over a 5 x 5 cm area of clipped skin and covered with gauss and then an impermeable bandage. The material was left on the skin for 24 hours after which the dressing was removed and the remaining material removed with warm water and the site blotted dry. Animals were observed for 14 days after removal of the dressing, were sacrificed on the 14th day after removal of the test substance, and submitted to a necropsy for examination of possible macroscopic effects on the major organs.
After 14 days of observation, body weight gained normally by animals. All organs appeared normal on necropsy. No adverse clinical signs were observed and the application site was free of local irritation throughout the 14 day observation period. No mortality was observed at dose 2000 mg/kg bw. Therefore, the LD50 value was considered to be >2000mg/kg bw, when rats were treated with 1,1,1-Tris(4-hydroxyphenyl)ethane (27955-94-8) by dermal application.
Thus, based on the above studies on 3-Bromoquinoline (CAS no 5332-24-1) and its read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 3-Bromoquinoline can be classified as category V of acute dermal toxicity.
Justification for classification or non-classification
Based on the above studies and pridiction on 3-Bromoquinoline (CAS no 5332-24-1) and its read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, 3-Bromoquinoline can be classified as category V of acute oral and dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.