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EC number: 401-100-0 | CAS number: 109037-78-7 TILCOM CA35; TILCOM IA10; TYTAN AP 100; TYTAN CA 100; TYTAN CX 35; TYZOR IAM
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritive database
- Title:
- Acute inhalation toxicity for CAS no: 126-71-6
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn).
- Reference Type:
- review article or handbook
- Title:
- Toxicological evaluation no.122 triisobutyl phosphate
- Author:
- BG Chemie
- Year:
- 2 000
- Bibliographic source:
- BG Chemie,Toxicological evaluation no.122 triisobutyl phosphate 11/2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Acute inhalation toxicity test was carried out to study the effects of Triisobutyl phosphate on rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Triisobutyl phosphate
- EC Number:
- 204-798-3
- EC Name:
- Triisobutyl phosphate
- Cas Number:
- 126-71-6
- Molecular formula:
- C12H27O4P
- IUPAC Name:
- Triisobutyl phosphate
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Triisobutyl phosphate
- Molecular formula :C12H27O4P
- Molecular weight :266.315g/mol
- Substance type:organic
- Physical state:No data available
- Purity:No data available
- Impurities (identity and concentrations):No data available
Test animals
- Species:
- rat
- Strain:
- other: Wistar(Hoe:WISKf/SPF71)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation:205-188g
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available - Water (e.g. ad libitum): No data available - Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available - Photoperiod (hrs dark / hrs light): No data available
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- 103 µm
- Geometric standard deviation (GSD):
- 1.6
- Details on inhalation exposure:
- No data available
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5.14 mg/L
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 21 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology were observed - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.14 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No deaths during study was observed.
- Clinical signs:
- other: Clinical signs included dyspnea, tremor, uncoordinated movements, a reduced level of spontaneous activity, ruffled fur, reduced startle reflexes and pinch reflexes, noses with bloody encrustations sneezing narrow palpebral fissure as well as reddish saliv
- Body weight:
- Body weight gain was impaired in the first week of post exposure observation. After 21 days the rats were free of symptoms again , with the exception of one female rats and their body weight had returned to normal
- Gross pathology:
- At necropsy at the end of the observation period approximately half of the animals exhibited discoloration of the lungs
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LC50 value for acute inhalation toxicity test was considered to be >5.140mg/L .when rats were exposed with Triisobutyl phosphate (126-71-6) by inhalation for 4 hour.
- Executive summary:
The acute inhalation toxicity study of Triisobutyl phosphate (126-71-6) was performed according to OECD guideline 403. 5 Male and 5 femaleWistar(Hoe:WISKf/SPF71) rats were exposed with test material in the concentration of 5.140mg/L inhaled (head/nose exposure ) for 4 hour. The median aerodynamic diameter being 1.3(with a geometric standard deviation of 1.6)All animals were observation for mortality and signs of toxicity for 21 days .No mortality were observed at dose concentration 5.140mg/L.Clinical signs included dyspnea, tremor, uncoordinated movements, a reduced level of spontaneous activity, ruffled fur, reduced startle reflexes and pinch reflexes, noses with bloody encrustations sneezing narrow palpebral fissure as well as reddish saliva and nasal discharge.
Body weight gain was impaired in the first week of post exposure observation. After 21 days the rats were free of symptoms again, with the exception of one female rats and their body weight had returned to normal. At necropsy at the end of the observation period approximately half of the animals exhibited discoloration of the lungs. HenceLC50value for acute inhalation toxicity testwas considered to be >5.140mg/L .when rats were exposed with Triisobutyl phosphate (126-71-6) by inhalation for 4 hour.
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