Registration Dossier
Registration Dossier
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EC number: 246-874-9 | CAS number: 25340-17-4
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity test data are available for fish, aquatic invertebrates and algae. Three studies were available for acute toxicity to freshwater fish. One study, identified as th key study, reported 96 -LC50 values for rainbow trout exposed to a 92.3% blend of diethylbenzene in a flow-through system. The diethylbenzene blend was comprised of equal volumes from three diethylbenzene samples. The diethylbenzene blend was prepared by combining 410-mL volumes from each diethylbemene sample into a 2-L glass carboy. The carboy was capped, shaken by hand, and then placed on an orbital shaker for one hour. The mixed contents in the carboy, diethylbenzene blend, were transferred to two appropriately labeled 32-once amber bottles. The final endpoint (LC50) after 96 -hours reported as active ingredient (a.i.) was 0.673 mg a.i./L. Two additional supporting studies determined 96 -hour LC50 values of 23 and 26 mg/L.
Three 48 -hour acute toxicity studies were available for Daphnia magna tested with diethylbenzene. A static renewal acute toxicity test was conducted with D. magna exposed to a 92.3% blend of diethylbenzene. This key study reported a 24-hour EC50 of >2.70 mg a.i./L, a 48-hour EC50 of 2.01 mg a.i./L and an NOEC equal to 1.07 mg a.i./L. Two supporting studies were also included. A static, nonrenewal study with D. magna reported a 48-hour EC50 value of 39 mg/L, while a third study with D. magna determined a 48-hour EC50 value of 8.9 mg/L.
The toxicity of diethylbenzene was determined in a key study two studies with the green algae, Pseudokirnereilla subcapitata (formerly known as Selenastrum capricornutum) exposed to a 92.3% blend of diethylbenzene. The study provided 72 -hour LC50 values of 1.21 and 1.0 mg/L for reduced growth rate and biomass. The 72 -hour NOEC was reported as 0.547 mg diethylbenzene/L. A supporting study was included with P. subcapitata tested with polyethylbenzene. The 96 -hour EC50 was 66 mg/L and the 96 -hour NOEC was 25 mg polyethylbenzene/L.
A sludge inhibition study with diethylbenzene following OECD 209 reported NOEC and EC50 values of greater than 1000 mg/L. Since the test substance is relatively insoluble in water with a solubility determined to be 15.7 mg/L at 20 degrees Celcius, the test substance was dosed by direct weight addition.
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