Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 445-890-5 | CAS number: 201290-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis half-life (silazane group): <1 minute at pH 4, pH 7 and pH 9 and 25°C (measured)
Hydrolysis half-life (diethoxy group): 0.4 hours at pH 4, 0.4 hours at pH 5, 10 hours at pH 7 and 0.2 hours at pH 9 at 20 - 25°C (QSAR)
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 min
- at the temperature of:
- 25 °C
Additional information
The submission substance, N,N-bis(trimethylsilyl)aminopropylmethyldiethoxysilane has two types of hydrolysable group; one silazane (Si-N-Si) and two ethoxy (-OCH2CH3) groups.
The silazane group is expected to hydrolyse very rapidly (instantaneously) in contact with water. This assumption is supported by a preliminary hydrolysis study conducted on the submission substance using a modified method in accordance with OECD 111/EC C.7. During the study, water at each pH was spiked with a known amount of the test substance and duplicate test solutions were prepared at each pH value. The diluted test solutions and blank were analysed using GC-FID; each sample was shaken, sampled and analysis was performed immediately at t=0 hours after fortification with the spiking solution. No peaks at the characteristic retention time of the test substance were observed in the GC chromatograms at time t=0 hours.
Also, an attempt was made to conduct a water solubility study for the submission substance using a modified method comparable to OECD Test Guideline 105 and in compliance with GLP (Young 2003). 100 mL water at 20°C was spiked with a solution of the test substance in 100 mL acetone, the solution was shaken, wrapped in aluminium foil to exclude light and sampled prior to placing in a water bath at 20°C. Duplicate samples were performed. Sampling of the test substance was performed at various time intervals of 0, 0.5 and 1 hour for test 1 and 0 hour only for test 2. Sample analysis was performed immediately after preparation using GC-FID. At t=0 h, t=0.5 h and t=1 h solutions, no peaks at the characteristic retention time of the test substance were observed in the chromatograms of the sample solution. This indicate that the test substance undergoes very rapid hydrolysis when in contact with water.
The silazane (Si-N-Si) group in contact with water undergoes instantaneous hydrolysis to form an intermediate hydrolysis product of 3-(diethoxy(methyl)silyl)propylamine and trimethylsilanol.
The hydrolysis half-lives of the intermediate hydrolysis product, 3-(diethoxy(methyl)silyl)propylamine have been determined using a validated QSAR estimation method. Hydrolysis half-life values of 0.4 hours at pH 4, 0.4 hours at pH 5, 10 hours at pH 7 and 0.2 hours at pH 9 and 20 -25°C were obtained for the intermediate hydrolysis product.
The products of hydrolysis of 3-(diethoxymethylsilyl)propylamine are 3-(dihydroxymethylsilyl)propylamine and ethanol.
Therefore, the ultimate hydrolysis products of the submission substance are trimethylsilanol, 3-(dihydroxymethylsilyl)propylamine and ethanol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)