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EC number: 240-915-4 | CAS number: 16883-16-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation:
The dermal irritation potential of 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor. The chemical 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) was estimated to be irritating to the skin of New Zealand White rabbits. Based on the estimated result 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) can be considered to be irritating to skin and can be classified under the category “Category 1”as per CLP regulation.
Eye irritation:
The ocular irritation potential of 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor. The chemical 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) was estimated to be not irritating into the eyes of New Zealand White rabbits. Based on the estimated result 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) can be considered to be not irritating to eye and can be classified under the category ˋ Not Classified’ as per CLP regulation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- data is from OECD QSAR toolbox v3.4 and the QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR toolbox v3.4
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 5-methyl-3-phenylisoxazole-4-carbonyl chloride
- Molecular formula: C11H8ClNO2
- Molecular weight: 221.642 g/mol
- Smiles notation: c1(ccccc1)c1c(C(=O)Cl)c(on1)C
- InChl: 1S/C11H8ClNO2/c1-7-9(11(12)14)10(13-15-7)8-5-3-2-4-6-8/h2-6H,1H3
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data available
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5ml
- Duration of treatment / exposure:
- 4 hours
- Number of animals:
- 6
- Details on study design:
- no data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Signs of irritation observed
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- 5-methyl-3-phenylisoxazole-4-carbonyl chloride was estimated to be corrosive to the skin of New Zealand White rabbits.
- Executive summary:
The dermal irritation potential of 5-methyl-3-phenylisoxazole-4-carbonyl chloride was estimated using OECD QSAR toolbox v3.4 with logPow as the primary descriptor.
5-methyl-3-phenylisoxazole-4-carbonyl chloride was estimated to be corrosive to the skin of New Zealand White rabbits.
Based on the estimated results, 5-methyl-3-phenylisoxazole-4-carbonyl chloride can be considered to be corrosive to skin and can be classified under the category “Category 1” as per CLP regulation.
Reference
Estimation
method: Takes mode value from the 7 nearest neighbours
Domain logical expression:Result: In Domain
((((((((((((((("a"
or "b" or "c" or "d" )
and ("e"
and (
not "f")
)
)
and ("g"
and (
not "h")
)
)
and ("i"
and (
not "j")
)
)
and ("k"
and (
not "l")
)
)
and ("m"
and (
not "n")
)
)
and ("o"
and (
not "p")
)
)
and "q" )
and "r" )
and "s" )
and "t" )
and "u" )
and "v" )
and "w" )
and ("x"
and "y" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Acyl halide OR Allyl OR Aryl OR
Ketoxime derivatives OR Oxazole/ Izoxazole OR Unsaturated heterocyclic
fragment by Organic Functional groups ONLY
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Acyl halide OR Allyl OR Aryl OR
Ketoxime derivatives OR Overlapping groups OR Oxazole/ Izoxazole OR
Unsaturated heterocyclic fragment by Organic Functional groups (nested)
ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] OR
Aliphatic Carbon [-CH2-] OR Aliphatic Carbon [-CH3] OR Aromatic Carbon
[C] OR Aromatic Nitrogen, five-member ring OR Aromatic Oxygen OR
Carbonyl, olefinic attach [-C(=O)-] OR Chlorine, olefinic attach [-Cl]
OR Miscellaneous sulfide (=S) or oxide (=O) OR Olefinic carbon [=CH- or
=C<] OR Oxygen, nitrogen attach [-O-] by Organic functional groups (US
EPA) ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aromatic compound OR Carbonic
acid derivative OR Halogen derivative by Organic functional groups,
Norbert Haider (checkmol) ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Non binder, impaired OH or NH2
group OR Non binder, MW>500 OR Non binder, non cyclic structure by
Estrogen Receptor Binding
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Inclusion rules not met by Skin
irritation/corrosion Inclusion rules by BfR
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Activated N-heterocycles OR
Aldehydes OR Epoxides(=oxiranes) OR Esters including acrylic and
methacrylic esters OR Ketones by Skin irritation/corrosion Inclusion
rules by BfR
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group All Lipid
Solubility < 0.01 g/kg AND (!Undefined)Group CNHal Lipid Solubility < 4
g/kg AND (!Undefined)Group CNHal Lipid Solubility < 400 g/kg by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group CNS Surface
Tension > 62 mN/m OR (N/A) OR Group All log Kow > 9 OR Group C Aqueous
Solubility < 0.0001 g/L OR Group C Melting Point > 55 C by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group All Lipid
Solubility < 0.01 g/kg AND (!Undefined)Group CNHal Lipid Solubility < 4
g/kg AND (!Undefined)Group CNHal Lipid Solubility < 400 g/kg by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Group CN Aqueous Solubility <
0.0001 g/L OR Group CN Aqueous Solubility < 0.1 g/L OR Group CN log Kow
> 4.5 OR Group CN log Kow > 5.5 by Skin irritation/corrosion Exclusion
rules by BfR
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group All Lipid
Solubility < 0.01 g/kg AND (!Undefined)Group CNHal Lipid Solubility < 4
g/kg AND (!Undefined)Group CNHal Lipid Solubility < 400 g/kg by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group C Surface
Tension > 62 mN/m by Skin irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 15
- Nitrogen N AND Group 16 - Oxygen O AND Group 17 - Halogens Cl AND
Group 17 - Halogens F,Cl,Br,I,At by Chemical elements
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Group 14 - Metalloids Si,Ge by
Chemical elements
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Acyl halide AND Allyl AND Aryl
AND Ketoxime derivatives AND Oxazole/ Izoxazole AND Unsaturated
heterocyclic fragment by Organic Functional groups ONLY
Domain
logical expression index: "s"
Referential
boundary: The
target chemical should be classified as Acyl halide AND Allyl AND Aryl
AND Ketoxime derivatives AND Oxazole/ Izoxazole AND Unsaturated
heterocyclic fragment by Organic Functional groups ONLY
Domain
logical expression index: "t"
Referential
boundary: The
target chemical should be classified as Acyl halide AND Allyl AND Aryl
AND Ketoxime derivatives AND Oxazole/ Izoxazole AND Unsaturated
heterocyclic fragment by Organic Functional groups ONLY
Domain
logical expression index: "u"
Referential
boundary: The
target chemical should be classified as Acyl halide AND Allyl AND Aryl
AND Ketoxime derivatives AND Oxazole/ Izoxazole AND Unsaturated
heterocyclic fragment by Organic Functional groups ONLY
Domain
logical expression index: "v"
Referential
boundary: The
target chemical should be classified as Acyl halide AND Allyl AND Aryl
AND Ketoxime derivatives AND Oxazole/ Izoxazole AND Unsaturated
heterocyclic fragment by Organic Functional groups ONLY
Domain
logical expression index: "w"
Referential
boundary: The
target chemical should be classified as Acyl halide AND Allyl AND Aryl
AND Ketoxime derivatives AND Oxazole/ Izoxazole AND Unsaturated
heterocyclic fragment by Organic Functional groups ONLY
Domain
logical expression index: "x"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 1.35
Domain
logical expression index: "y"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 2.17
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- data is from OECD QSAR toolbox v3.3 and the QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- The study was conducted following a protocol based on BASF-internal standards.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 5-methyl-3-phenylisoxazole-4-carbonyl chloride
- Molecular formula: C11H8ClNO2
- Molecular weight: 221.642 g/mol
- Smiles notation: c1(ccccc1)c1c(C(=O)Cl)c(on1)C
- InChl: 1S/C11H8ClNO2/c1-7-9(11(12)14)10(13-15-7)8-5-3-2-4-6-8/h2-6H,1H3
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- no data available
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- upto 72 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- no data available
- Other effects / acceptance of results:
- no data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of irritation observed
- Interpretation of results:
- other: not irritating
- Conclusions:
- 5-methyl-3-phenylisoxazole-4-carbonyl chloride was estimated to be not irritating to the eyes of New Zealand White rabbits.
- Executive summary:
The ocular irritation potential of 5-methyl-3-phenylisoxazole-4-carbonyl chloride was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor.
5-methyl-3-phenylisoxazole-4-carbonyl chloride was estimated to be not irritating to the eyes of New Zealand White rabbits.
Based on the estimated results, 5-methyl-3-phenylisoxazole-4-carbonyl chloride can be considered to be not irritating to eyes and can be classified under the category “Not Classified” as per CLP regulation.
Reference
Estimation
method: Takes mode value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
((((((("a"
or "b" or "c" or "d" )
and ("e"
and (
not "f")
)
)
and "g" )
and "h" )
and ("i"
and (
not "j")
)
)
and ("k"
and (
not "l")
)
)
and ("m"
and "n" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Acyl halide OR Allyl OR Aryl OR
Ketoxime derivatives OR Oxazole/ Izoxazole by Organic Functional groups
ONLY
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Acyl halide OR Allyl OR Aryl OR
Ketoxime derivatives OR Overlapping groups OR Oxazole/ Izoxazole by
Organic Functional groups (nested) ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aliphatic Carbon [CH] OR
Aliphatic Carbon [-CH2-] OR Aliphatic Carbon [-CH3] OR Aromatic Carbon
[C] OR Aromatic Nitrogen, five-member ring OR Aromatic Oxygen OR
Carbonyl, olefinic attach [-C(=O)-] OR Chlorine, olefinic attach [-Cl]
OR Miscellaneous sulfide (=S) or oxide (=O) OR Olefinic carbon [=CH- or
=C<] OR Oxygen, nitrogen attach [-O-] by Organic functional groups (US
EPA) ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aromatic compound OR Carbonic
acid derivative OR Halogen derivative by Organic functional groups,
Norbert Haider (checkmol) ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Non binder, impaired OH or NH2
group OR Non binder, MW>500 OR Non binder, non cyclic structure by
Estrogen Receptor Binding
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Class 3 (unspecific reactivity)
by Acute aquatic toxicity classification by Verhaar (Modified) ONLY
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Reactive unspecified by Acute
aquatic toxicity MOA by OASIS ONLY
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Inclusion rules not met by Skin
irritation/corrosion Inclusion rules by BfR
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Epoxides(=oxiranes) by Skin
irritation/corrosion Inclusion rules by BfR
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group All Lipid
Solubility < 0.01 g/kg AND (!Undefined)Group CNHal Lipid Solubility < 4
g/kg AND (!Undefined)Group CNHal Lipid Solubility < 400 g/kg by Skin
irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group CN Lipid
Solubility < 0.4 g/kg by Skin irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "m"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 1.35
Domain
logical expression index: "n"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.21
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
Various studieshas been investigated for the test chemical5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2)to observe the potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) and its structurally similar read across substances2-Phenylpropene (CAS No: 98-83-9)andBenzoyl chloride (CAS No: 98-88-4).The predicted data using the OECD QSAR toolbox has also been compared with the experimental data which are summarized as below;
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the skin irritation potential was estimated for test chemical5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2). The test substance 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) is estimated to be irritating to skin of New Zealand White Rabbits.
The MAK Collection for Occupational Health and Safety {The MAK Collection for Occupational Health and Safety, 138–140, 2012} conducted a skin irritation study of read across substance 2-Phenylpropene(CAS No:- 98-83-9) in rabbits. In this test, undiluted test chemical was applied to the shaved skin of rabbits under a bandage for 2 to 4 weeks (10 to 20 applications). The rabbits showed moderate to severe irritation and slight necrosis was also observed. Hence, the test chemical 2-Phenylpropene (CAS No: 98-83-9) was considered to be irritating to the shaved skin of rabbits.
The above results were further supported by the dermal irritation study reported by the American Chemistry Council Benzoates Panel {Robust summary and test plans: benzoyl chloride; The American Chemistry Council Benzoates Panel; 2003} for read across substance Benzoyl chloride (CAS No: 98-88-4). The test was performed according to Draize method. The hair was clipped from the backs of 3 male and 3 female New Zealand White rabbits; the skin of 3 animals was abraded.0.5 ml of Benzoyl chloride was applied to clipped back skin and the wrapped with a gauze bandage. Four hours later the bandage was removed and the area washed with tepid water. The test sites were observed and scored immediately after patch removal and at 24, 72 hours. The Primary Irritation Index of benzoyl chloride after 24 and 72 hours was 3.8 Based on the scores, Benzoyl chloride can be considered to be irritating to rabbit skin.
Thus based on the available data for the target substance 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) and its structurally similar read across substances2-Phenylpropene (CAS No: 98-83-9)andBenzoyl chloride (CAS No: 98-88-4),it can be concluded thatchemical 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) is able to cause severe skin irritation and considered as irritating. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 1”.
Eye irritation:
In different studies,test chemical5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2)has been investigated for potential for ocular irritation to a greater or lesser extentThe studies are based on in vivo experiments in rabbits for target chemical5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2)and its structurally similar read across substancesSodium benzoate (CAS No: 532-32-1) and Methyl benzoylformate (CAS No: 15206-55-0).The predicted data using the OECD QSAR toolbox has also been compared with the experimental data which are summarized as below;
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the eye irritation potential was estimated for test chemical5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2).The chemical 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) is estimated to be not irritating to eye of New Zealand White rabbits.
The IFA (GESTIS) {GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften), 2017} carried out an ocular irritation study of read across substance Sodium benzoate (CAS No: 532-32-1) in humans. The chemical Sodium benzoate was instilled into human eyes and effects were observed (dose and duration not specified). Under the conditions of the study, sodium benzoate was not irritating to human eyes.
Another eye irritation study of same read across substance Sodium benzoate (CAS No: 532-32-1) was conducted in rabbits according to Directive 84/449/EEC by OECD SIDS {SIDS Initial Assessment Report for 13th SIAM - Benzoates, 2001}. No known effects were observed when the chemical was applied into the eye of rabbits. Hence the chemical Sodium benzoate (CAS No: 532-32-1) was considered to be not irritating to rabbit eyes.
The above results were further supported by the experimental study reported by EUROPEAN COMMISSION – European Chemicals Bureau (IUCLID DATASET for 15206-55-0; EUROPEAN COMMISSION – European Chemicals Bureau, 2000) for read across substance Methyl benzoylformate (CAS No: 15206-55-0). The study was performed according to OECD 405. Rabbits were instilled Methyl benzoylformate in to the eyes and observed for signs of irritation (dose and duration not mentioned). No signs of irritation were observed after instillation of Methyl benzoylformate. Hence, Methyl benzoylformate can be considered to be not irritating to rabbit eyes.
Thus on the basis of available data for thetarget chemical5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) and its structurally similar read across substancesSodium benzoate (CAS No: 532-32-1) and Methyl benzoylformate (CAS No: 15206-55-0),it can be concluded thatchemical 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) is unable to cause eye irritation and considered as not irritating. Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Not Classified”.
Justification for classification or non-classification
The skin and eye irritation potential of test chemical 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) and its structurally similar read across substanceswere observed in various studies. The results obtained from these studies indicate that the chemical 5-methyl-3-phenylisoxazole-4-carbonyl chloride is likely to cause severe skin irritation but not able cause ocular damage. Hence 5-methyl-3-phenylisoxazole-4-carbonyl chloride (CAS No: 16883-16-2) can be classified under the category “Category 1” for skin and “Not Classified” for eye as per CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.