Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-512-0 | CAS number: 35325-02-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- ECOSAR is an accepted and well validated QSAR model for prediction of the short term toxicity to fish
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARS R6 May 2008
- Principles of method if other than guideline:
- ECOSAR is a general model for aquatic toxicity of organic substances. In ECOSAR, substances for which the ecotoxicity is estimated are entitled to chemical classes according to their chemical structure. For each class the ecotox values for acute and chronic endpoints are estimated.
- GLP compliance:
- no
- Test type:
- other: QSAR modeled data
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 6 197 mg/L
- Details on results:
- validity: see QMRF - QPRF
add results ECOSAR - Conclusions:
- The estimated 96-hr LC50 value for fish for N-(2-hydroxypropyl)benzenesulphonamide is 6197 mg/l (ECOSAR, v1.10).
- Executive summary:
The aquatic toxicity was estimated using the ECOSAR model v1.10 included in the EpiSuite models of US-EPA. In ECOSAR, substances for which the ecotoxicity is estimated are entitled to chemical classes according to their chemical structure. For each class the ecotox values for acute and chronic endpoints are estimated. N(2 -hydroxypropyl)benzenesulfonamide is classified under the class of the Neutral Organics. The estimated 96 -hr LC50 value for fish is 6197 mg/l.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 6 197 ng/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
