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EC number: 240-714-1 | CAS number: 16669-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation: sensitising
Respiratory tract sensitisation: Due to the very low vapour pressure of the substance and the resulting lack of significant exposure, respiratory tract sensitisation is not considered as relevant.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
With a very low water solubility of <1 µg/L dermal uptake of Docosyl methacrylate from the stratum corneuminto the epidermis is likely to be low. With log Pow> 6 the rate of transfer between thestratum corneumand the epidermis will be slow and will limit absorption across the skin. Uptake into thestratum corneumitself is expected to be slow. For the alkyl-methacrylate esters, their absorption rates correlate with their molecular volume in the sense that smaller esters permeate membranes more rapidly than larger esters. Therefore, C12-22 methacrylates are expected to be absorbed to a very low extend.
Only after special treatment, docosyl methacrylate could be made bioavailable.To be tested in the LLNA, the solid waxy test material had to be heated up to 50° C and then dissolved in methylethyl ketone. Under these special conditions Docosyl methacrylate was at least partly made bioavailable and showed a sensitizing potential in the LLNA. TheEC3 based on the thymidine incorporation was determined to be 9.3%; the EC1.5 based on the cell count stimulation index was 19.4%. (BASF SE, 2018)
In a dermal sensitization study with 2-Propenoic acid, 2-methyl-, C16-20-alkyl esters dissolved in acetone : olive oil (4 +1, v/v) as a vehicle, 16 (4 per dose group) 7 week old female CBA/CaOlaHsd mice were tested using the LLNA method of OECD TG 429. Three groups each of four female mice were treated daily with the test item at concentrations of 2.5 %, 5 % and 10 % (w/v) in acetone/olive oil (4/1, v/v) by topical application. In the course of the study no cases of mortality were observed. Neither clinical / local signs nor were other findings observed in any animals of the control group, Group 2 (2.5 %) or Group 3 (5 %). One day after the first topical application, slight ear erythema was observed at both dosing sites in all mice of Group 4 (10 %), persisting for a total of two days. In this study Stimulation Indices (S.I.) of 0.9, 0.9, and 1.9 were determined with the test item at concentrations of 2.5, 5.0, and 10% in acetone : olive oil (4 +1, v/v), respectively. No dose-response relationship was observed. The EC3 value could not be determined because this calculation requires a S.I. value of greater than 3. The test item is not a dermal skin sensitizer (Evonik RohMax GmbH UNTER 06-018).
A further LLNA was conducted using a conventional protocol according OECD TG 429. The test article was Isotridecyl methacrylate delivered in a 4:1 mixture of acetone and olive oil (AOO) with the selected test concentrations being (w/v) 12.5 % and 25%. In the group treated with 25% test item concentration on day 1-3, a distinct lymphocyte proliferation was observed (S.I. = 3.06). However, as the response of animals challenged with 25% test item on day 16 (S.I. = 1.43) was lower and not distinctly higher than the primary response obtained with the same test item concentration directly after the sensitization phase, it can be concluded that the induced response does not bear any immunological memory. Thus, the lymphocyte proliferation observed in the sensitization phase is not due to a sensitizing effect but results from irritation caused by the test item as also supported by the ear weight data. This is also supported by the fact that in the group treated with 12.5% test item concentration (day 1-3), where no relevant increase in ear weights (no irritation) was observed in comparison to the control group, the obtained S.I. was below the threshold of 3. On this basis the clear interpretation is that the test article Isotridecyl methacrylate lacks the potential to cause skin sensitization (Evonik RohMax GmbH UNTER 10-022).
The third LLNA was conducted using according OECD TG 429. The test article was a long-chain methacrylate ester 17.4 (C16-C20 main constituents approximately 28 % hexadecyl methacrylate and 65 % octadecyl methacrylate) delivered in a 4:1 mixture of acetone and olive oil (AOO) with the selected test concentrations being (w/v) 2.5%, 5% and 10%. At none of these test concentrations was an SI of 3 or greater achieved relative to concurrent vehicle control values (2.5% = SI of 0.9; 5% = SI of 0.9; 10% = 1.9). On this basis the clear interpretation is that methacrylic acid ester 17.4 lacks the potential to cause skin sensitization (Evonik RohMax GmbH UNTER 09-004).
Conclusion
Docosyl methacrylate has a sensitizing potential.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Respiratory sensitisation
Due to the very low vapour pressure of the substance and the resulting lack of significant exposure, respiratory tract sensitisation is not considered as relevant.
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The substance is considered to be classified for skin sensitisation under Regulation (EC) No. 1272/2008, as amended for the tenth time in Regulation (EU) No. 2017/776. Skin Sens. 1B; H317: May cause an allergic skin reaction.
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