Registration Dossier
Registration Dossier
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EC number: 279-979-3 | CAS number: 82493-14-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Hostavin 3206
Toxicokinetics
There are no studies available in which the toxicokinetic properties of the substance were investigated.
The test item is a viscous and organic substance, and it is hydrolytically stable (see IUCLID chapter 5.1.2). The water solubility is not determinable (see IUCLID chapter 4.8). The octanol water partition coefficient (Log Pow) for the substance was determined to be 4.4 (see IUCLID chapter 4.7). Due to the water insolubility a general potential of bioaccumulation can be excluded.
Absorption
With reference to the insolubility in water and its complex structure the absorption of the substance is considered to be restricted (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, Table R.7.12-1, p. 168). Furthermore, even if low amounts of the substance are dissolved in aqueous solutions it might dissociate into ionic species (i.e. N+). Ionisation does not contribute to a readily diffusion across biological membranes (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 167). Therefore, an excessive absorption of the substance can be excluded. This assumption is strengthened by the results of several oral toxicity studies in rats (acute oral toxicity study: LD50> 10,000 mg/kg bw; OECD 422 study: NOAEL 1000 mg/kg bw/d (no adverse changes observed in all dose groups).
Distribution
The substance is not water soluble. Therefore, it will not migrate into cells and concentrate in adipose tissues or other systemic compartments (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, pp. 176-177).
Metabolism
Taking into account the water insolubility and the results of several oral toxicity studies, an uptake of considerable amounts of this substance is not considered to occur. However, absorption of marginal amounts can not be excluded.
Studies on genotoxicity performed with the test item and its structural analogue (Ames-Test; HPRT test and chromosome aberration study) were negative, i.e. there is no indication of a reactivity of the substance under the test conditions. With reference to its chemical composition and structure the cleavage of the acid-amide binding might be considered as possible metabolic pass way.
Excretion
With reference to the limited solubility the biliary excretion might be considered as the most favorable excretion route. Therefore, enterohepatic recycling resulting in a prolonged biological half-life can not be excluded (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 178).
Key value for chemical safety assessment
Additional information
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