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EC number: 276-333-2 | CAS number: 72089-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 - 30 Jun 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- No information on purity was given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- no data on purity of test substance; body weight was not determined weekly.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- β,2,2,3-tetramethylcyclopent-3-ene-1-butanol
- EC Number:
- 276-333-2
- EC Name:
- β,2,2,3-tetramethylcyclopent-3-ene-1-butanol
- Cas Number:
- 72089-08-8
- Molecular formula:
- C13H24O
- IUPAC Name:
- β,2,2,3-tetramethylcyclopent-3-ene-1-butanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: BOR: WISW
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 156.9 - 210.0 g (males), 140.0 - 178.0 g (females)
- Fasting period before study: 16 h prior to and approx. 4 h after dosing
- Housing: in groups of maximum 5 animals in Macrolon cages (Typ III) on sawdust
- Diet: Ssniff-R Alleindiät für Ratten (Ssniff Versuchstierdiäten GmbH, Soest, Germany), ad libitum
- Water: ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 45 - 55
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 7.5 mL/kg bw
- Doses:
- Range-finding study: 2.5, 5.0 and 7.5 mL/kg bw
Main study: 2.5, 3.75, 5.0 and 7.5 mL/kg bw (corresponding to 2250, 3375, 4500 and 6750 mg/kg bw based on density of 0.9 g/cm³) - No. of animals per sex per dose:
- Range-finding study: 2 females
Main study: 5 males and 5 females - Control animals:
- no
- Details on study design:
- Range-finding study:
- Duration of observation period following administration: 14 days
Main study:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were recorded 15 and 45 min and 1.5, 3, 6, 24 and 48 h after administration and on Days 4 and 14. Individual body weights were determined on Days 0 and 14.
- Necropsy of survivors performed: yes - Statistics:
- Probit Analysis according to Finney was used to calculate the oral LD50 values.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Remarks:
- calculated using Probit Analysis acc. to Finney
- Effect level:
- 5.24 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: (corresponding to 4716 mg/kg bw based on density of 0.9 g/cm³)
- Mortality:
- Range-finding study: All animals died at 5.0 and 7.5 mL/kg bw within 48 h after administration. No mortality occurred at 2.5 mL/kg bw.
Main study: At 2.5 mL/kg bw no mortality occurred during the study period. At 3.75 mL/kg bw one male and one female died within 24 and 48 h, respectively, after administration. At 5.0 mL/kg bw two males and one female died within 24 h and two females died within 48 h after administration. At 7.5 mL/kg bw four males and one female died within 24 h and 3 females died within 48 h after administration. - Clinical signs:
- other: Disturbed awareness with apathy, abnormal body posture, disturbance of coordination, reduced reflex excitability, cyanosis, piloerection and reduced respiration rate were observed. The symptoms were observed 15 min after administration and lasted in survi
- Gross pathology:
- Gross pathological examination of dead animals revealed redness and partly liquid accumulation in the entire digestive system. No gross pathological findings were observed in rats sacrificed at study termination.
Any other information on results incl. tables
Table 1. Mortality.
Dose (mL/kg bw) |
Males |
Females |
2.5 |
0/5 |
0/5 |
3.75 |
1/5 |
1/5 |
5.0 |
2/5 |
3/5 |
7.5 |
4/5 |
4/5 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- In this acute oral toxicity study a LD50 value of 5.24 mL/kg bw (corresponding to 4716 mg/kg bw based on density of 0.9 g/cm³) was derived in male and female rats.
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