Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-976-0 | CAS number: 130-14-3
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/ sediment:
Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3) is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical sodium naphthalene-1-sulfonate is non-bioaccumulative in food chain.
Additional information
Bioaccumulation: aquatic/ sediment:
Various predicted data for the target compound sodium naphthalene-1 -sulfonate (CAS No. 130 -14 -3) and supporting weight of evidence study for its read across substance were reviewed for the bioaccumulation end point which are summarized as below:
In first study BCF value of test chemical was estimated by using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3) is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical sodium naphthalene-1-sulfonate is non-bioaccumulative in food chain.
Next study was reviewed from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance sodium naphthalene-1-sulfonate (CAS no. 130 -14 -3) was estimated to be 5.83 dimensionless. The predicted BCF result was based on the 5 OECD principles. Thus based on the result it is concluded that the test substance sodium naphthalene-1-sulfonate is non-bioaccumulative in nature.
Another study was reviewed from authoritative database (J check, 2018) in this study the Bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test substance under static conditions. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances". Test chemical nominal conc. used for the study were 10 mg/l and 1 mg/l (w/v). Range finding study involve the TLm (48 hr) ≥ 4000 mg/l on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of test substance on Cyprinus carpio was determined to be < 0.6 L/Kg at a conc. of 10 mg/l and < 6 L/Kg at a conc. of 1 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
Further, to support above mentioned studies another study was reviewed from authoritative database (HSDB, 2017) in this study the bioaccumulation experiment was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using an estimated log Kow of -0.14 and a regression derived equation. The BCF (bioaccumulation factor) value of test chemical was determined to be 0.5 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.
Last study was reviewed from authoritative database (J check, 2018) in this study Bioaccumulation experiment was conducted on test organism Cyprinus carpio for 8 weeks for evaluating the bioconcentration factor (BCF value) of test substance under static conditions. Test chemical nominal conc. used for the study were 5 mg/l and 0.5 mg/l (w/v). Range finding study involve the TLm (48 hr) 610 mg/l on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of test substance on Cyprinus carpio was determined to be< 0.6 L/Kg at a conc. of 5 mg/l and < 6 L/Kg at a conc. of 0.5 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
On the basis of above results for target chemical sodium naphthalene-1-sulfonate (from, EPI suite, CompTox Chemistry Dashboard, 2017) and for its read across substance (from authoritative database HSDB and J-CHECK, 2017), it can be concluded that the BCF value of test substance sodium naphthalene-1-sulfonate was in range from 3.162 to 5.83 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical sodium naphthalene-1 -sulfonate is not expected to bioaccumulate in the food chain
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
