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EC number: 228-937-2 | CAS number: 6375-46-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- IUCLID Dataset
- Author:
- OECD
- Year:
- 2 004
- Bibliographic source:
- IUCLID Dataset - OECD -30-JUL-2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An ocular irritation study of Trimellitic anhydride (CAS no: 552-30-7) was conducted on one New Zealand albino rabbits in order to examine the degree of eye irritation caused by the chemical .
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3-dioxo-1,3-dihydro-2-benzofuran-5-carboxylic acid
- Cas Number:
- 552-30-7
- Molecular formula:
- C9H4O5
- IUPAC Name:
- 1,3-dioxo-1,3-dihydro-2-benzofuran-5-carboxylic acid
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Trimellitic anhydride (TMA)
- Molecular formula: C9H4O5
- Molecular weight: 192.1256 g/mol
- Substance type: Organic
- Physical state: Solid
-Smiles: c1cc2c(cc1C(=O)O)C(=O)OC2=O
-InChI: 1S/C9H4O5/c10-7(11)4-1-2-5-6(3-4)9(13)14-8(5)12/h1-3H,(H,10,11)
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Trimellitic anhydride (TMA)
- Molecular formula: C9H4O5
- Molecular weight: 192.1256 g/mol
- Substance type: Organic
- Physical state: Solid
-Smiles: c1cc2c(cc1C(=O)O)C(=O)OC2=O
-InChI: 1S/C9H4O5/c10-7(11)4-1-2-5-6(3-4)9(13)14-8(5)12/h1-3H,(H,10,11)
- Purity :98%
-Impurities:2%
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the other eye serving as the untreated control.
- Amount / concentration applied:
- Amount:1 00mg (0.1 g)
concentration applied: 100% - Duration of treatment / exposure:
- 14 days
- Observation period (in vivo):
- 1, 2, 3, 4, 7, and 14 days following test article administration
- Number of animals or in vitro replicates:
- 1 (male/female)
- Details on study design:
- - Area of exposure: one of the eye
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- 110
- Max. score:
- 110
- Reversibility:
- not reversible
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- A reaction was considered positive if at any observation period, the test article produced ulceration or opacity of the cornea (cornea score > than 0), inflammation or slight circumcorneal injection of blood vessels of the iris (iris score > 0), any obvious conjunctival swelling with partial eversion of the lids (chemosis score 2 or greater), or conjunctival erythema of diffuse crimson red (erythema score 2 or greater) with individual vessels not easily discernable.
- Other effects:
- Signs of ocular irritation were maximum (i.e. Draize score 110/110) at the 24 hour examination and the study was terminated immediately thereafter with no dosing of any additional animals. The maximum eye irritation score of 110/110 was obtained 1 day after administration of test article.
Any other information on results incl. tables
DERMALIRRITATION SCORES |
||||||
Skin reactions |
Mean scores (time) |
|||||
30-60mins |
24 hours |
48 hours |
2 hours |
Day 7 |
Day 14 |
|
Edema score |
1.8 |
1.0 |
0.3 |
0.3 |
0.0 |
0.0 |
Erythema and eschar formationscore |
2.5 |
1.2 |
1.0 |
0.8 |
0.7 |
0.0 |
Irritation score |
4.3 |
2.2 |
1.3 |
1.1 |
0.7 |
0.0 |
Irritation score= mean Edema score + mean Erythema score |
||||||
primary dermal irritation score (PDIS) =1.7 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The maximum eye irritation score of 110/110 was obtained 1 day after administration of Trimellitic anhydride. Thus chemical Trimellitic anhydride (CAS no: 552-30-7) was considered to be severely irritating irritating irritant to the eye of New Zealand albino rabbit.
- Executive summary:
An ocular irritation study of Trimellitic anhydride (CAS no: 552-30-7) was conducted on one New Zealand albino rabbits in order to examine the degree of eye irritation caused by the chemical.
It was anticipated that TMA might be a severe eye irritant. Therefore, out of concern for animal pain and discomfort, only one rabbit was used initially as a test subject.
TMA was administered undiluted at a dose of 100mg (0.1mg) into one eye with the other eye serving as the untreated control. The treated eye was scored for irritation at 1, 2, 3, 4, 7, and 14 days following test article administration. Irritation was scored using the Draize method. A reaction was considered positive if at any observation period, the test article produced ulceration or opacity of the cornea (cornea score > than 0), inflammation or slight circumcorneal injection of blood vessels of the iris (iris score > 0), any obvious conjunctival swelling with partial eversion of the lids (chemosis score 2 or greater), or conjunctival erythema of diffuse crimson red (erythema score 2 or g greater) with individual vessels not easily discernable.
Signs of ocular irritation were maximum (i.e. Draize score 110/110) at the 24 hour examination and the study was terminated immediately thereafter with no dosing of any additional animals.
The maximum eye irritation score of 110/110 was obtained 1 day after administration of Trimellitic anhydride.Thus chemicalTrimellitic anhydride (CAS no: 552-30-7) was considered to be severely irritating to theeyeofNew Zealand albinorabbit.
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