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Diss Factsheets
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EC number: 204-606-8 | CAS number: 123-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 January - 8 February 1949
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted prior to GLP and Test guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 949
- Report date:
- 1949
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Groups of male rats were orally gavaged with test material and observed for two weeks.
- GLP compliance:
- no
- Test type:
- other: Range finding study
Test material
- Reference substance name:
- 2,6,8-trimethylnonan-4-ol
- EC Number:
- 204-606-8
- EC Name:
- 2,6,8-trimethylnonan-4-ol
- Cas Number:
- 123-17-1
- Molecular formula:
- C12H26O
- IUPAC Name:
- 2,6,8-trimethylnonan-4-ol
- Details on test material:
- - Name of test material (as cited in study report): 2,6,8-trimethyl nonanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No additional information available.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% Tergitol 7 aqueous solution
- Details on oral exposure:
- Test material was a 20% dispersion in 1% Tergitol 7
- Doses:
- Rats were dosed with 7950, 15,800 and 31,600 mg/kg.
- No. of animals per sex per dose:
- 5 males/dose level
- Control animals:
- no
- Details on study design:
- Rats were orally gavaged with a 20% solution in 1% Tergitol 7. Animals were observed for two weeks.
Rats weight ranged from 90 - 118 grams at time of dosing. - Statistics:
- Method of Thompson used to calculate Range Finding LD50.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 13 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 11 200 - 16 700
- Mortality:
- 31,600 mg/kg
Five of five rats died following dosing. Two rats died one day after dosing while three died two days after dosing.
15,800 mg/kg
Two of five rats died following dosing. One rat died one day and the other died two days after dosing.
7950 mg/kg
Zero of five rats died following dosing. - Clinical signs:
- other: There were no remarkable symptoms evident after dosing.
- Gross pathology:
- Congestion of the visceral organs was observed.
- Other findings:
- No additional information available.
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the study results, Trimethyl nonanol is a compound of low acute oral toxicity for rats with a range finding LD50 of 17,000 (12,200 to 23,800) mg/kg. It is a member of the same oral toxicity grade as ethanol.
- Executive summary:
The acute oral toxicity of trimethyl nonanol was examined. The oral LD50 in male rats was 17,000 (12,200 - 23,800) mg/kg.
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