Registration Dossier
Registration Dossier
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EC number: 205-447-7 | CAS number: 141-01-5
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
The study does not need to be conducted because the substance is readily biodegradable.
Biodegradation in water:
The percentage degradation of test substance was determined to be 70 and 87 % by BOD and 100 % by TOC removal and HPLC parameter in 14 days. Thus, based on percentage degradation, test chemical was considered to be readily biodegradable in water.
Biodegradation in water and sediment:
In accordance with column 2 of Annex IX of the REACH regulation, testing for this end point is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable in water.
Biodegradation in soil:
In accordance with column 2 of Annex IX of the REACH regulation, testing for this end point is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable in water.
Bioaccumulation: Aquatic / sediment:
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for test substance was estimated to be 4.94 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus, based on the result it is concluded that the test substance is non-bioaccumulative in nature.
Adsorption/desorption:
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the adsorption i.e Koc for test substance was estimated to be 8.69 dimensionless. (Log Koc is 0.939). This Koc value indicates that the test chemical has a negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.
Additional information
Hydrolysis:
The study does not need to be conducted because the substance is readily biodegradable.
Biodegradation in water:
Summarized result for the determination of biodegradation of test chemical and structurally and functionally similar read across chemicals in water are as mentioned below:
In the first key study from authoritative database, biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of test substance. Activated sludge was used for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance concentration used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 70 and 100 % by BOD, TOC removal and HPLC parameter in 14 days. Thus, based on percentage degradation, test chemical was considered to be readily biodegradable in water.
Above study further supported by the second study from authoritative database. Biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of test substance. Activated sludge was used for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance concentration used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 87 % by BOD and 100% by TOC removal and HPLC parameter in 14 days. Thus, based on percentage degradation, test chemical was considered to be readily biodegradable in water.
Thus, on the basis of above all studies, the percentage degradation of test substance was determined to be 70 and 87 % by BOD and 100 % by TOC removal and HPLC parameter in 14 days. Thus, based on percentage degradation, test chemical was considered to be readily biodegradable in water.
Biodegradation in water and sediment:
In accordance with column 2 of Annex IX of the REACH regulation, testing for this end point is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable in water.
Biodegradation in soil:
In accordance with column 2 of Annex IX of the REACH regulation, testing for this end point is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable in water.
Bioaccumulation: Aquatic / sediment:
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for test substance was estimated to be 4.94 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus, based on the result it is concluded that the test substance is non-bioaccumulative in nature.
Adsorption/desorption:
Summarized result for the determination of adsorption of test chemical and structurally and functionally similar read across chemicals are as mentioned below:
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the adsorption i.e Koc for test substance was estimated to be 8.69 dimensionless. (Log Koc is 0.939). This Koc value indicates that the test chemical has a negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.
Above data further supported by the second weight of evidence report. The Koc of test chemical was determined using a structure estimation method based on molecular connectivity indices. The Koc of test chemical can be estimated to be 7 (Log Koc is 0.845), using a structure estimation method based on molecular connectivity indices. This Koc value indicates that the test chemical has a negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.
Based on the data obtained from the authoritative database, the Koc of test chemical was determined using a structure estimation method based on molecular connectivity indices. The Koc of test chemical can be estimated to be 7 (Log Koc is 0.845), using a structure estimation method based on molecular connectivity indices. This Koc value indicates that the test chemical has a negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.
Thus, on the basis of above all data from various sources, the log Koc value of test chemical ranges from 0.845 to 0.939, which indicates that the chemical has a negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.
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