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EC number: 246-905-6 | CAS number: 25371-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 31, 2004 - April 22, 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Deviations:
- yes
- Remarks:
- The dose preparations were not analysed to confirm test article concentration, stability or homogeneity. This deviation is not considered to adversely effect the outcome of this study
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl hydrogen octadecylphosphonate
- EC Number:
- 246-905-6
- EC Name:
- Methyl hydrogen octadecylphosphonate
- Cas Number:
- 25371-55-5
- Molecular formula:
- C19H41O3P
- IUPAC Name:
- methoxy(octadecyl)phosphinic acid
- Reference substance name:
- Octadecylphosphonic acid
- EC Number:
- 225-216-4
- EC Name:
- Octadecylphosphonic acid
- Cas Number:
- 4724-47-4
- Molecular formula:
- C18H39O3P
- IUPAC Name:
- octadecylphosphonic acid
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Test material form:
- solid
Constituent 1
impurity 1
impurity 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Animals were housed individually in suspended stainless steel cages. All housing and care were based on the standards recommended by the Guide for the Care and Use of Laboratory AnimalsEnvironmental ConditionsRoom temperature: 20-23°CRelative Humidity: 39-59%Light cycle: 12-hour light/ 12-hour dark cycleRoom ventilation: 10-15 air changes/hour
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- On day -1, the animals chosen for the limit test were weighed and fasted overnight. Pnr day 0, the test article was administered orally as a single dose using a ball tipped stainless steel gavage needle attached to a syringe
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 females/ dose group
- Control animals:
- no
- Details on study design:
- A limit test was performed in which one female rat was initially dosed a single oral administration fo the test article at a dose of 2000 mg/kg body weight. Two further female rats received a single oral administration of the test article at the same dose level. The study was then completed with two additional females. Following dosing, the rats were observed daily and weighed weekly. A gross necropsy examination was performed on all animals at the time of scheduledd euthanasia (day 14).
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- Clinical signs of toxicity oberved during th study included transient incidences of congested breathing, few feces, soft stools, mucoid stools, feces small in size, rough coat and fecal stain.
- Body weight:
- Slight body weight loss was noted in one female furing the study day 7 to 14 body weight interval. Body weight gain was noted for all other animals during the test period.
- Gross pathology:
- No gross internal findings were observed at necropsy on study day 14.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of this study the LD50 value of Phosphonic acid, octadecyl,-monomethyl ester is considered to be > 2000 mg/kg body weight
- Executive summary:
A limit test was performed in which one female was initially dosed a single oral administration of test article at a dose of 2000 mg/kg body weight. Since there were no clinical observations, two additional female rats received a single oral administration of the test article at the same dose level. The study was then completed with additional females. No mortality occured during the study. Clinical signs of toxicity were limited to transient incidences of congested breathing, few feces, soft stools, feces small in size, rough coat and fecal stain. Slight body weight loss was noted in one female during study day 7 to 14. No gross internal findings were observed at necropsy on study day 14.
Under the conditions of this test, the acute oral LD50 of Phosphonic acid, octadecyl,-monomethyl ester is considered to be > 2000 mg/kg body weight.
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