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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Pre-GLP study, similar to OECD TG 401, meets generally accepted scientific principles, acceptable for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
test was done before GLP came into force
Test type:
standard acute method
Limit test:
yes

Test material

1
Chemical structure
Reference substance name:
(Z)-hex-3-enyl benzoate
EC Number:
246-669-4
EC Name:
(Z)-hex-3-enyl benzoate
Cas Number:
25152-85-6
Molecular formula:
C13H16O2
IUPAC Name:
(3Z)-hex-3-en-1-yl benzoate
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Details on study design:
- Observation period: 14 days
- Frequency of observations: daily

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
1 of 10 rats was observed dead at day 2.
Clinical signs:
other: Slight lethargy

Applicant's summary and conclusion

Interpretation of results:
other: Not Classified
Remarks:
Criteria not met according to EU CLP 1272/2008 and its amendments
Conclusions:
The acute oral toxicity test showed an LD50 of > 5000 mg/kg bw. Therefore the substance does not need to be classified according to GHS.
Executive summary:

Acute oral toxicity: In this study, 10 rats were administered the substance at a dose level of 5000 mg/kg bw. Slight lethargy was observed and one of ten rats was observed dead at day two. The acute oral LD50 for the substance was determined to be > 5000 mg/kg bw. Therefore the substance does not need to be classified for acute oral toxicity according to EU CLP 1272/2008 and its amendments.