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EC number: 212-606-4 | CAS number: 831-59-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal .
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Zinc Phenolsulfonate
- Author:
- Cosmetic Ingredient Review panel
- Year:
- 1 986
- Bibliographic source:
- JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY,Volume 5, Number 5, 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- To evaluate the skin sensitizing potential of Zinc bis(4-hydroxybenzenesulfonate) in Hartley albino guinea pigs by Buehler test.
- GLP compliance:
- not specified
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- Not specified.
Test material
- Reference substance name:
- Zinc bis(4-hydroxybenzenesulfonate
- Cas Number:
- 127-82-2
- Molecular formula:
- C6H6O4S.1/2Zn
- IUPAC Name:
- Zinc bis(4-hydroxybenzenesulfonate
- Details on test material:
- - Name of test material (as cited in study report): Zinc Phenolsulfonate
- Molecular formula (if other than submission substance): C6H6O4S.1/2Zn
- Molecular weight (if other than submission substance): 411.725g/mol
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Zinc Phenolsulfonate
- Molecular formula (if other than submission substance): C6H6O4S.1/2Zn
- Molecular weight (if other than submission substance): 411.725g/mol
- Substance type: Organic
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Remarks:
- albino
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available.
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- other: Ethanol
- Concentration / amount:
- 0.5 ml dose of a 16% (w/v)
- Day(s)/duration:
- 6 hour
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Acetone.
- Concentration / amount:
- 16% (w/v) solution
- Day(s)/duration:
- 24 and 48 h
- No. of animals per dose:
- Test group-20 animals
Control group-10 animals - Details on study design:
- Details on study design
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period:6 hour
- Test groups:20
- Control group:10
- Site: A test material was applied to the clipped back skin of the test animals.
- Frequency of applications: No data available
- Duration: 6 hour
- Concentrations: 16% (w/v)
.
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: 2-week
- Exposure period: 24 and 48 hour
- Test groups: 20
- Control group:10
- Site: A test material was applied to the clipped back skin of the test animals.
- Concentrations: 16% (w/v)
- Evaluation (hr after challenge): 24 and 48 hourafter patch removal. - Challenge controls:
- Yes 10 control animals were used.
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available.
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: challenge
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 16% (w/v)
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No skin sensitization effects were observed.
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- other: Challenge
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 16% (w/v)
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No skin sensitization reaction was observed.
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
No skin sensitization reaction was observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: Non sensitizing.
- Conclusions:
- Zinc bis(4-hydroxybenzenesulfonate (127-82-2) was observed for its skin sensitizing potential in Hartley albino guinea pigs by Buehler test. Zinc bis(4-hydroxybenzenesulfonate (127-82-2) was considered to be not sensitizing in in Hartley albino guinea pigs by Buehler test.
- Executive summary:
Zinc bis(4-hydroxybenzenesulfonate (127-82-2)was assessed for its possible contact allergenic potential. For this purpose Buehler test was performed on a group of 20 Hartley albino guinea pigs. In induction exposure 0.5 ml dose of a 16% (w/v) of test material and ethanol as a vehicle was applied to the clipped back skin of the test animals. Three exposures of 6 h each comprised the induction phase. After a 2-wee of rest period, a challenge patch was applied to the site using a 16% (w/v) solution of the test material in acetone. The test sites were scored 24 and 48 h after application of the challenge patch. No sensitization reactions were reported. ThereforeZinc bis(4-hydroxybenzenesulfonate (127-82-2) was considered to be non sensitizing in Hartley albino guinea pigs by Buehler test.
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