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EC number: 216-381-3 | CAS number: 1570-64-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Taken from EU Risk Assessment Report - Reviewed by the Danish Environmental Protection Agency. Guideline Study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 4-chloro-o-cresol
- EC Number:
- 216-381-3
- EC Name:
- 4-chloro-o-cresol
- Cas Number:
- 1570-64-5
- Molecular formula:
- C7H7ClO
- IUPAC Name:
- 4-chloro-2-methylphenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: Individually caged.
- Diet (e.g. ad libitum): conventional laboratory diet
- Water (e.g. ad libitum): Unlimited supply
- Acclimation period: at least 5 days prior to the test
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C +/- 3°C
- Humidity (%): 30-70%
- Air changes (per hr): Not specified
- Photoperiod (hrs dark / hrs light): 12 hours light/12 hours dark
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: arachidis oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal area of the trunk
- % coverage: approximately 10% of the total body suface area
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Residual test material removed by washing with water or a suitable solvent 24 hours after dosing.
- Time after start of exposure: 24hours
- Duration of exposure:
- 24 hours
- Doses:
- The doses tested were as follows:
1,667, 2,000, 2,400 and 2,880 mg PCOC - No. of animals per sex per dose:
- There were 5 male and 5 female rats per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 240 mg/kg bw
- Remarks on result:
- other: Range 2023 -2484 mg/kg/bw
- Mortality:
- See table below (Table 1) for mortality details
- Clinical signs:
- During the first 24 hours after treatment blood was observed in the urine of all the rats. The day after treatment erythema and oedema were observed at the application sites. Paresis occurred in nearly all the animals 1-6 hours after treatment.
Depressions occurred up to 2 days after treatment and ruffled fur up to 3 days after treatment. - Gross pathology:
- At necropsy, bleeding of the lungs, a mucous, red-yellow content of the jejunum (intestine), enlarged kidneys and blood or blood coagulum in the bladder and bleeding of the bladder walls were all observed.
In animals sacrificed on day 14, weak bleeding of the intestine was observed in five of the rats, the dose levels were not stated.
Any other information on results incl. tables
Table 1. Summary of mortality rates.
Dose Level, mg/kg bw | Mortality (out of 10) | Time Period |
1667 | 0/10 | - |
2000 | 4/10 | within 1 day of dosing |
2400 | 6/10 | within 1 day of dosing |
2880 | 9/10 | within 6 hours of dosing |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified as harmful in contact with skin
- Remarks:
- Criteria used for interpretation of results: other: Approved Classification and Labelling Guide (Sixth Edition), Chemicals (Hazard Information and Packaging for Supply) Regulations 2009 (CHIP 4)
- Conclusions:
- Based on the results obtained in this study, 4-chloro-o-cresol is not classified as harmful in contact with skin.
- Executive summary:
A guideline study was performed on groups of five male and five female rats at dose levels ranging from 1667 - 2880 mg/kg bw.
In the 2880 mg/kg dose group 9 animals died within 6 hours of dosing, in the 2400 mg/kg dose group 6 animals died within 1 day of dosing, in the 2000 mg/kg dose group 4 animals died within 1 day of dosing, no animals died in the 1667 mg/kg dose group.
At necropsy bleeding of the lungs, a mucous, red-yellow content of the jejunum (intestine), enlarged kidneys and blood or blood coagulum in the bladder and bleeding of the bladder walls were all observed.
In animals sacrificed on day 14, weak bleeding of the intestine was observed in five of the rats; the dose levels were not stated.
During the first 24 hours after treatment blood was observed in the urine of all the rats. The day after treatment erythema and oedema were observed at the application sites. Paresis occurred in nearly all the animals 1-6 hours after treatment. Depressions occurred up to 2 days after treatment and ruffled fur up to 3 days after treatment. The LD50 was derived to be 2240 mg/kg/bw.
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