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EC number: 283-518-1 | CAS number: 84650-59-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Illicium verum, Illiciaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (E)-anethole
- EC Number:
- 224-052-0
- EC Name:
- (E)-anethole
- Cas Number:
- 4180-23-8
- Molecular formula:
- C10H12O
- IUPAC Name:
- 1-methoxy-4-prop-1-en-1-ylbenzene
- Reference substance name:
- 4-allylanisole
- EC Number:
- 205-427-8
- EC Name:
- 4-allylanisole
- Cas Number:
- 140-67-0
- Molecular formula:
- C10H12O
- IUPAC Name:
- 1-allyl-4-methoxybenzene
- Reference substance name:
- Caryophyllene
- EC Number:
- 201-746-1
- EC Name:
- Caryophyllene
- Cas Number:
- 87-44-5
- Molecular formula:
- C15H24
- IUPAC Name:
- 4,11,11-trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene
- Reference substance name:
- 2,6-dimethyl-6-(4-methyl-3-pentenyl)bicyclo[3.1.1]hept-2-ene
- EC Number:
- 241-702-9
- EC Name:
- 2,6-dimethyl-6-(4-methyl-3-pentenyl)bicyclo[3.1.1]hept-2-ene
- Cas Number:
- 17699-05-7
- Molecular formula:
- C15H24
- IUPAC Name:
- 2,6-dimethyl-6-(4-methylpent-3-en-1-yl)bicyclo[3.1.1]hept-2-ene
- Test material form:
- liquid
Constituent 1
Constituent 2
1
Constituent 3
Sampling and analysis
- Details on sampling:
- Test substance information
Test item: Essential Oil of Star Anise Oil (Illicium verum)
Common name of the active ingredient (a.i.) UVCB substance (1)
Received on: 17/May/2018
Bioagri code: QUIM-0014/18
Analyzed Concentration of a.i. (Bioagri): 96.32% (w/w)
Analysis Certificate (CA): CA TH – 0461/17 R1
Batch number: 18-02-10-1 (1)
Test Substance sent by: Jinxi County Purong Essences Mfg Co., Ltd (1)
Manufacturer: Jinxi County Purong Essences Mfg Co., Ltd (1)
Address: JiangXi Jinxi County Industrial Park Area C (1)
Physical state: Light yellow clarified liquid or crystal (1)
Manufacture Date: 10/Feb/2018 (1)
Validity Date: 09/Aug/2019 (1)
Source: (1) Information provided by the sponsor.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Water Milli-Q
Sodium 1-heptanesulfonate 99%
Methanol 99.9%
Bacteriological Peptone
Meat Extract
Urea 99%
Sodium Chloride 99%
Calcium chloride 98%
Magnesium Sulfate 98%
Potassium phosphate 98%
Deionized water
Copper sulphate penta hydrate 98.22%
Water without chlorine
Test organisms
- Test organisms (species):
- activated sludge of a predominantly industrial sewage
- Details on inoculum:
All chemicals used in the test were “analytical grade” or “for use in microbiology”.
Composition of nutrient solution (synthetic sewage):
Peptone 16.0 g
Beef extract 11.0 g
Urea 3.0 g
NaCl 0.7 g
CaCl2 *2H2O 0.4 g
MgSO4 *7H2O 0.2 g
K2HPO4 2.8 g
Deionised water 1000 mL
The pH of the solutions was 7.52. The medium was prepared and stored in the dark at a temperature of 4°C.
Study design
- Water media type:
- freshwater
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- 20±2℃
- pH:
- 7.52
- Nominal and measured concentrations:
- One replicate/treatment (positive control)
One replicate for concentration (10 mg L-1)
One replicate for concentration (100 mg L-1)
Three replicates for concentration (1000 mg L-1) - Details on test conditions:
- The study was performed in a closed system with aeration. In the control vessels, 16 mL of nutrient solution was mixed with 234 mL of water. The positive control and the test vessels were prepared by adding the appropriate amount of positive control solution respectively test item into the test vessel, adding 16 mL nutrient solution and water to give 250 mL. Then, 250 mL inoculum was added in ten minutes intervals. After addition of the inoculums, the flasks were closed immediately and the mixtures were stirred with aeration.
After three hours the contents were poured into a tube of approximately 50 mL and the respiration rate was determined by measuring the O2 concentration over a ten minutes period. The following vials were measured equally at ten minutes intervals. - Reference substance (positive control):
- yes
- Remarks:
- copper sulfate pent hydrate
Results and discussion
Effect concentrations
- Key result
- Duration:
- 3 h
- Remarks on result:
- other: there were no statistically significant toxic effects at the highest concentration (1000 mg L-1)
- Details on results:
- The test substance was solubilized in water because of its solubility. As there were no statistically significant toxic effects at the highest concentration (1000 mg L-1), no further testing was required at higher or lower concentrations as outlined in OECD 209, 2010.
- Results with reference substance (positive control):
- Variation in O2-Consumption of the Controls
Average oxygen uptake rate was 66.50 mg L-1 h. The variation of OD consumption in the controls was 15.71% which are far below the recommended upper limit of 30%.
Any other information on results incl. tables
Table 6. O2-Consumption, Inhibition - test substance.
Test Concentration |
pH |
Consumption (mg L-1h) |
Inhibition (%) |
Variation in DO consumption of controls (%) |
Control C1 |
7.65 |
56.05 |
- |
15.71 |
F1 – 1% |
8.01 |
66.50 |
0.00 |
|
F2 – 10% |
7.83 |
70.30 |
0.00 |
|
F3 – 100% |
8.00 |
66.50 |
0.00 |
|
F3 – 100% |
8.00 |
61.75 |
0.00 |
|
F3 – 100% |
7.89 |
67.45 |
0.00 |
|
Abiotic control |
7.24 |
0.00 |
- |
|
Control C2 |
8.01 |
66.50 |
- |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- As there were no statistically significant toxic effects at the highest concentration (1000 mg L-1), no further testing was required at higher or lower concentrations as outlined in OECD 209, 2010.
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