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Diss Factsheets
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EC number: 204-473-6 | CAS number: 121-47-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Predates implementation of GLP and/or development of study guidelines, available as unpublished report, limitations in design and/or reporting acceptable with restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Six albino rabbits were used, the hair was clipped from the back of each of these animals. The test material was applied as 40% suspension in 1% aqueous carboxymethyl cellulose to each of three rabbits with intact skin and to each of three rabbits with abraided skin. The volume of the test material applied was approximately 2.0 mL per rabbit, which was spread and rubbed evenly onto the skin and into the abrasions once a day on five days of the week, over a period of 14 days.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 3-aminobenzenesulphonic acid
- EC Number:
- 204-473-6
- EC Name:
- 3-aminobenzenesulphonic acid
- Cas Number:
- 121-47-1
- Molecular formula:
- C6H7NO3S
- IUPAC Name:
- 3-aminobenzene-1-sulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): Metanilic Acid Cake, Ba 38/76, TR 76-415 (M53740; UM 44)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 1.89 - 2.11 kg
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: 1% aqueous carboxymethyl cellulose
- Details on exposure:
- TEST SITE
- Area of exposure: the back
- Coverage: 12 x 18 cm per rabbit; covered approximately 10% of the total body surface of a rabbit
- Type of wrap if used: no data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.0 mL per rabbit
- Concentration (if solution): 40% suspension in 1% aqueous carboxymethyl cellulose. - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- Once a day on five days of the week.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
40% suspension in 1% aqueous carboxymethyl cellulose
Basis:
- No. of animals per sex per dose:
- 6 animals (3 with intact skin, 3 with abraided skin)
- Control animals:
- not specified
- Details on study design:
- no data
Examinations
- Observations and examinations performed and frequency:
- DERMAL IRRITATION (if dermal study): Yes
BODY WEIGHT: Yes
CAGE SIDE OBSERVATIONS: Yes
URINALYSIS: Yes - Sacrifice and pathology:
- no data
Results and discussion
Results of examinations
- Details on results:
- The compound produced no signs of local irritation. The abraided areas had healed nearly completely at the end of the two-week period. The gain in body weight of rabbits was above normal. (average body weight gain intact skin group 0.73 kg, abraided skin group 0.61 kg). Compound is brown in color, and stained the skin and fur light brown. The urine of all animals had a brownish color, indicating that a portion of the compounds applied was absorbed. Signs of systemic intoxication were not noted.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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