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Diss Factsheets
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EC number: 944-461-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Aug - 6 Sep 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: SEPA, The Guidelines for the Testing of Chemicals, 2004, 203 Fish Acute Toxicity Test.
- Deviations:
- no
- Principles of method if other than guideline:
- Gobiocypris rarus is suitable for fish toxicity testing because of their ease of culturing and handling, sensitivity to a variety of chemical substances, and the extensive data base for this species. This species complies with SEPA, The Guidelines for the Testing of Chemicals, 2004, 203 Fish Acute Toxicity Test and OECD Guidelines for the Testing of Chemicals. 203 Fish, Acute Toxicity Test 1992.
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all
- Sampling method: 2 mL of test solution was taken from each test vessel at the beginning and at the end of the test
- Sample storage conditions before analysis: none - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: nominal concentration of 100 mg/L of the test substance was prepared and stirred (via magnetic stirrer) in the dark for 72 h at 500 rpm followed by filtration using a 0.451 μm nitrocellulose membrane to make a saturated solution of the test substance in the test water. - Test organisms (species):
- other: Gobiocypris rarus
- Details on test organisms:
- TEST ORGANISM
- Common name: rare minnow
- Source: Institute of Hydrobiology, Chinese Academy of Sciences
- Length at study initiation (mean and SD): not stated
- Weight at study initiation (mean and SD): not stated
- Method of breeding: not stated
- Feeding during test: none
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions:
Water dechlorinated by activated carbon and sterilized by UV lamp
Temperature: 21-25 °C (+/- 2 °C)
pH: 6.0-8.5
Photoperiod: light: dark = 12 hours : 12 hours
- Type and amount of food: not stated
- Feeding frequency: daily until 24 hours before the test was started
- Health during acclimation (any mortality observed): no diseases were observed during the acclimation period; no mortality occurred within the 7 days before the start of the test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
- Hardness:
- 155 mg CaCO3/L
- Test temperature:
- 23.4 - 24.0 °C
- pH:
- 7.1 - 7.5
- Dissolved oxygen:
- 65.8 - 84.7% ASV (air saturation value)
- Nominal and measured concentrations:
- 0 and 100 mg/L (saturated solution, nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 5L glass tanks were used containing 4L test solution
- Type (delete if not applicable): not stated
- Aeration: no
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.6 g fish/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water, dechlorinated by activated carbon and sterilized by UV lamp, was used. The water was aerated continuously over 24h
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: light: dark = 12 hours : 12 hours
- Light intensity: not stated
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
mortality at 0, 24, 48, 72 and 96 hours
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 0 and 100 mg/L (saturated solution, nominal)
- Results used to determine the conditions for the definitive study: LC50 > 100 mg/L (saturated solution, nominal) - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: test material (saturated solution)
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Measured concentrations of the test substance were below the limit of detection of 89.6 ng/mL
- Details on results:
- There was no acute toxicity of the saturated solution in the limit test. The 96h LC50 of the test substance to Gobiocypris rarus was higher than the concentration of the saturated solution (which measured concentration was below the LOD2, LOD2=89.6 ng/mL) under the tested conditions.
- Sublethal observations / clinical signs:
Table 1. Mortalities and abnormalities in limit test:
Group Duration (h) Mortalities [%] Abnormalities Control 0 0 none 24 0 none 48 0 none 72 0 none 96 0 none 100 mg/L (nominal, saturated solution) 0 0 none 24 0 none 48 0 none 72 0 none 96 0 none Table 2. Measured concentrations of the test substance in limit test:
Treatment group Measured concentrations [mg/L] 0h 96h Control not detected not detected 100 mg/L (nominal, saturated solution) not detected not detected
Reference
Description of key information
LC50 (96 h) > 100 mg/L (nominal) for Gobiocypris rarus (OECD 203).
Key value for chemical safety assessment
Additional information
The study by Jing (2014), which examines the short term toxicity of Reaction mass of 1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromo-2-methylpropoxy)benzene] and 1,3-dibromo-2-(2,3-dibromo-2-methylpropoxy)-5-{2-[3,5-dibromo-4-(2,3,3-tribromo-2-methylpropoxy)phenyl]propan-2-yl}benzene to fish, was conducted according to OECD guideline 203 and GLP. In a static test system with freshwater, the test organism Gobiocypris rarus, was exposed to a single concentration of 100 mg/L (nominal). The test item was found to be poorly soluble in water and therefore its solution was stirred and filtrated prior to test initiation, in order to prepare a saturated solution. The analytical monitoring via UPLC showed that the concentration of the test substance was below the limit of detection (89.6 ng/mL) during the test. No mortalities were observed during the 96 h test period and the LC50 was determined to be > 100 mg/L (nominal).
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