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EC number: 215-223-0 | CAS number: 1314-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant, guideline study, available as unpublished report, fully adequate for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- The age of test organisms at test start was of maximum 29 hours old, instead of less than 24 hours old.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- yes
- Remarks:
- The age of test organisms at test start was of maximum 29 hours old, instead of less than 24 hours old.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Duplicate sampling from all test concentrations and controls were taken at the start of the test and at the end of the test. All samples were stored in a refrigerator prior to analysis.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A stock solution was prepared by dissolving 20 mg test item into 200 mL test water (100 mg/L) by intense stirring for 10 minutes. Afterwards, 4 mL of this stock solution were diluted to 200 mL with test water to prepare a solution of 2 mg/L. Then, this solution was diluted with test water to prepare test media.
- Controls: test water without addition of the test item
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): not reported - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain/clone: Straus, Clone 5
- Source: Umweltbundesamt, Institut für Wasser-, Boden- und Lufthygiene, Berlin, Germany
- Age of parental stock: not reported
- Age of test organisms: 22.5 hours to 29 hours
- Feeding during test: none
ACCLIMATION
- Acclimation period: 6 hours and 40 minutes
- Acclimation conditions (same as test or not): same as test
- Type and amount of food: not reported
- Health during acclimation (any mortality observed): not reported - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- None
- Hardness:
- 250 mg/L as CaCO3
- Test temperature:
- 21 °C
- pH:
- 7.0 - 7.6
- Dissolved oxygen:
- 8.4 - 9.0 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 20, 29, 42, 62 and 90 μg test item/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beakers containing 50 mL of test solution
- Aeration: not reported
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water
- Total Hardness: 250 mg/L as CaCO3
- Alkalinity: 0.8 mmol/L
- Ca/mg ratio: 4 : 1 (based on molarity)
- Conductivity: < 5 μS/cm
- Intervals of water quality measurement:
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light and 8 hours dark
- Light intensity: 60 - 100 lux
EFFECT PARAMETERS MEASURED: The immobility or mortality of Daphnia was determined every 24 hours. Daphnia were considered immobile if they were unable to swim for 15 seconds after gentle agitation.
VEHICLE CONTROL PERFORMED: no
RANGE-FINDING STUDY
- Test concentrations: not reported
- Results used to determine the conditions for the definitive study: not reported - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 60.8 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95 % Confidence Intervals: 56.6 - 65.3 μg test item/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 20.48 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- pt
- Basis for effect:
- mobility
- Remarks on result:
- other: 95 % Confidence Intervals: 19.06 - 21.99 μg Pt/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 42 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 14.15 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Pt
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 62 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 20.88 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Pt
- Basis for effect:
- mobility
- Details on results:
- After 48 hours of exposure, the toxicity of the test item to Daphnia magna increased. In the control and up to 42 μg test item/L, no significant immobility or mortality or other signs of intoxication were determined. At the test concentration of nominal 62 μg test item /L, 11 organisms were found to be immobile, and at the highest test concentration of 90 μg test item/L, all organisms were immobile at the end of the test.
- Reported statistics and error estimates:
- The 48-hour EC50 and 95 % confidence intervals were calculated by Probit analysis. The NOEC and LOEC values were determined by Fisher's Exact Test with Bonferroni Correction (alpha is 0.05).
Statistical calculations were performed with ToxRat. - Validity criteria fulfilled:
- yes
- Remarks:
- The validity criteria were fulfilled as no Daphnia were immobilised in the control and the dissolved oxygen was greater than 3 mg/L at the end of the test
- Conclusions:
- Based on nominal concentrations, the 48-hour EC50 of hexachloroplatinic acid to Daphnia magna was determined to be 60.8 μg test item/L (20.48 μg Pt/L).
- Executive summary:
A 48-h acute immobilisation Daphnia magna study is available for hexachloroplatinic acid. The study is reliable without restrictions, being GLP-compliant, and having followed standard guidelines (OECD 202 and EU Method C.2).
A static test system was followed. Five nominal test concentrations were used and these were analysed using Graphite furnace-AAS method. Although stock solution concentration was confirmed by analytical monitoring the test concentrations were not measured. All validity criteria were met. Based on nominal concentrations, the 48-hour EC50 of hexachloroplatinic acid to Daphnia magna was determined to be 60.8 μg test item/L (20.48 μg Pt/L). The 48-hour NOEC was determined to be 42 μg test item/L (14.15 μg Pt/L), and the 48-hour LOEC was determined to be 62 μg test item/L (20.88 μg Pt/L).
Reference
Table 1. Effect of hexachloroplatinic acid on the mobility of Daphnia magna after 24 and 48 hours of exposure.
Concentration (μg test item/L) | No. of organisms tested | No. of immobilised organisms after | % of immobilised organisms after | ||
24 hours | 48 hours | 24 hours | 48 hours | ||
control | 20 | 0 | 0 | 0 | 0 |
20 | 20 | 0 | 0 | 0 | 0 |
29 | 20 | 0 | 0 | 0 | 0 |
42 | 20 | 0 | 0 | 0 | 0 |
62 | 20 | 0 | 11 | 0 | 55* |
90 | 20 | 4 | 20 | 20 | 100* |
* Statistically significant according to Fisher's Exact Test (alpha: 0.05)
Description of key information
No experimental study is required for platinum dioxide based on the outcome of a full TDp assay (cfr.
IUCLID Section 4 'Water solubility') and the identified acute and chronic threshold values with other
water soluble platinum(IV) substances.
The 48-hour EC50 for hexachloroplatinic acid was determined at 20.48 μg Pt L-1. This is the lowest acute threshold identified with Platinum(IV) substances, and this value serves as basis for acute ERV derivation.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 20.48 µg/L
Additional information
No experimental study is required for platinum dioxide based on the outcome of a full TDp assay (cfr.
IUCLID Section 4 'Water solubility') and the identified acute and chronic threshold values with other
water soluble platinum(IV) substances.
A 48-h acute immobilisation Daphnia magna study is available for hexachloroplatinic acid following OECD guideline 202 and EU Method C.2 (Moll and Wydra 2005). A static test system was used. Five nominal test concentrations were used and these were analysed using Graphite furnace-AAS method. The concentration of the test item could not be quantified, since all concentrations were below the LOQ. Results were therefore based on nominal concentrations. At the start of the test animals were of maximum 29-h old, instead of less than 24-h old, and this was reported as a protocol deviation. However, the experiment was still considered to be valid. The 48-hour EC50 was determined to be 60.8 μg test item L-1 (20.48 μg Pt L-1). The 48-hour NOEC was determined to be 42 μg test item L-1 (14.15 μg Pt L-1), and the 48-hour LOEC was determined to be 62 μg test item L-1 (20.88 μg Pt L-1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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