Registration Dossier
Registration Dossier
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EC number: 813-266-5 | CAS number: 45101-66-4
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
6-chlorohexyl methacrylate is expected to be stable at neutral and acidic pH and to hydrolyze under alkaline condition as other methacrylates esters.
Key value for chemical safety assessment
Additional information
No data is available regarding the stability in water of 6-chlorohexyl methacrylate but its behaviour in water is expected to be similar to short chain alkyl methacrylates and in particular to the most similar substance 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier). As reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) methacrylate esters are stable at neutral and acidic pH. Under alkaline conditions at pH 9 or 11 significant hydrolysis is observed with a trend to a decrease of the hydrolysis rate with increasing chain length and branching. This is partly due to increased steric hindrance and partly due to decreasing alkoxide stability during ester cleavage. Under normal environmental conditions, abiotic degradation by hydrolysis is not expected to play an important role in the degradation of methacrylates in the environment. In particular, experimental data are available for the most similar short chain alkyl methacrylates 2-ethylhexyl methacrylate (2-EHMA) CAS 688-84-6. In SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) inside the specific section of 2 -EHMA a study conducted in 1997 according to OECD 111 is reported: 2-EHMA was stable at pH 4 and at pH 7 at 50 °C and the half life for this substance at pH=9 at T=25°C was 58.7 days. (Ref. CERI, 1998, Report No. 80670DK, CERI, Chemicals Evaluation and Research Institute, Japan, unpublished data on 2-EHMA).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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