Registration Dossier
Registration Dossier
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EC number: 249-050-7 | CAS number: 28479-22-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
For 3-chloro-p-tolyl isocyanate and the main hydrolysis product 3 -chloro-4-methylaniline no short-term tests on toxicity to aquatic plants are available. Therefore, the short-term toxicity test of the structural analogue/surrogate 3,4-dichloroaniline with the lowest value is used to draw a conclusion on toxicity to aquatic plants for the 3 -chloro-p-tolyl isocyanate. Concerning the acute toxicity of 3,4-dichloroaniline to aquatic plants (Scenedesmus pannonicus), a study was performed according to a national standard method: determination of the toxic effect on the growth of algae. After 96 h exposure, a EC50 of 4.8 mg/l and a NOEC of 1.0 mg/l was obtained (Adema 1982). The short-term toxicity test of the structural analogue/surrogate 4 -chloroaniline with the lowest value is used to support the conclusion on toxicity to aquatic plants for the 3 -chloro-p-tolyl isocyanate. The acute toxicity of 1 -amino-4 -chlorobenzene with respect to the inhibition of growth of Scenedesmus subspicatus is 6.3 mg/l (IC50) after 72 hours of exposure (Kuehn, 1990).
Key value for chemical safety assessment
Additional information
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