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Diss Factsheets
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EC number: 207-321-7 | CAS number: 462-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: short-term inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
- Reference Type:
- publication
- Title:
- Toxicological Evaluations Vol. 13
- Author:
- BG Chemie
- Year:
- 1 998
- Bibliographic source:
- Springer-Verlag Berlin Heidelberg, ISBN 3-540-62658-1
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- Principles of method if other than guideline:
- The TS was administered by nose only inhalation to three groups, each of five male and five female rats for 28 consecutive days at target concentrations of 0.4, 1.5 and 6.0 mg/L. A control group was exposed to air only.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Fluorobenzene
- EC Number:
- 207-321-7
- EC Name:
- Fluorobenzene
- Cas Number:
- 462-06-6
- Molecular formula:
- C6H5F
- IUPAC Name:
- fluorobenzene
- Details on test material:
- - Purity > 99.9%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 168-212 g; females: 136-188 g
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: air
- Details on exposure:
- Nose-only inhalation
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Gas chromatography
- Duration of treatment / exposure:
- 28 days, 6 hours/day
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.4 mg/L air (nominal)
- Remarks:
- equals 0.37 mg/L analytical concentration
- Dose / conc.:
- 1.5 mg/L air (nominal)
- Remarks:
- equals 1.50 mg/L analytical concentration
- Dose / conc.:
- 6 mg/L air (nominal)
- Remarks:
- equals 6.24 mg/L analytical concentration
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, sham-exposed
Examinations
- Observations and clinical examinations performed and frequency:
- Clinical signs, bodyweight, food and water consumptions were monitored during the study together with specific neurotoxicity functional observations. Haematology, blood chemistry and urinalysis were evaluated for all animals at the end of the study.
- Neurobehavioural examinations performed and frequency:
- The rats underwent a detailed neurological examination on days 13 and 27 (males) or days 14 and 28 (females) of the study. The criteria examined
included behavioural, functional, motor and sensory disturbances and reflex behaviour (25 parameters in total). - Sacrifice and (histo)pathology:
- All animals were subjected to a gross necropsy examination and fluoride analysis was subsequently carried out on pooled samples of sternum bone and teeth. Limited histopathological evaluation of tissues was performed on all animals from all groups.
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 0.37 mg/L air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- histopathology: non-neoplastic
Any other information on results incl. tables
No signs of fluorobenzene having neurotoxic activity could be detected.
Applicant's summary and conclusion
- Conclusions:
- No signs of fluorobenzene having neurotoxic activity could be detected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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