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EC number: 267-510-5 | CAS number: 67874-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- to be filled
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 10707:1994. Water quality - Evaluation in an aqueous medium of the "ultimate" aerobic biodegradability of organic compounds -Method by analysis of biochemical oxygen demand (closed bottle test)
- Deviations:
- no
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: 1. Secondary activated sludge, domestic, non-adapted; 2. river water
- Details on inoculum:
- ACTIVATED SLUDGE
Secondary activated sludge was obtained from the wastewater treatment plant Nieuwgraaf in Duiven, The Netherlands. This plant is an activated sludge plant treating predominantly domestic wastewater. The activated sludge was preconditioned to reduce the endogenous respiration rates. To this end, 400 mg Dry Weight (DW)/L of activated sludge was aerated for one week. The sludge was diluted in the BOD bottles (van Ginkel and Stroo, 1992).
RIVER WATER
River water was sampled from the Rhine near Heveadorp, The Netherlands. The nearest plant (Arnhem-Zuid) treating domestic wastewater biologically was 3 km upstream. The river water was aerated for 7 days before use to reduce the endogenous respiration. River water without particles was used as inoculum. The particles were removed by sedimentation. - Duration of test (contact time):
- 56 d
- Initial conc.:
- 2 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST BOTTLES
The test was performed in 0.3 L BOD (biological oxygen demand) bottles with glass stoppers.
STOCK SOLUTION
Administration of Cedryl Methyl Ether was accomplished by dosing 0.03 g of Cedryl Methyl Ether on 10 g of silica gel in a 50-mL serum flask. Only part of the top layer of the silica gel was brought into contact with the test substance. The serum flask was closed with a screw top with alumiminium foil and the content was mixed vigorously. Subsequently 0.2 g of silica gel dosed with Cedryl Methyl Ether was added to the test bottles. The resulting concentration of test substance in the bottles was 2.0 mg/L. Next the bottles were filled with nutrient medium with inoculum or river water and closed.
TEST PROCEDURES
Use was made of 3 bottles containing inoculum and silica gel, and 3 bottles containing inoculum and silica gel dosed with test substance. The concentration of the test substance in the bottles was 2.0 mg/L. Each of the prepared solutions was dispensed into the respective group of BOD bottles so that all bottles were completely filled without air bubbles. The bottles were immediately analyzed for dissolved oxygen using an oxygen electrode. The bottles with magnetic stirrer bars were subsequently closed. These bottles were incubated at 23±1°C in the dark. Oxygen concentrations at days 7, 14, 21, 28, 42 and 56 were measured using a special funnel. This funnel fitted exactly in the BOD bottle. Subsequently, the oxygen electrode was inserted in the BOD bottle to measure the oxygen concentration. The medium dissipated by the electrode was collected in the funnel. After withdrawal of the oxygen electrode the medium collected flowed back into the BOD bottle, followed by removal of the funnel and closing of the BOD bottle (van Ginkel and Stroo 1992).
TEST CONDITIONS
The pH of the media with activated was 7.0 at the start of the test. The pH of the medium at day 28 was 7.0 (control) and 7.1 (test). The pH of the river water with and without test substance at start and end of the test ranged from 7.8 to 8.6. Temperatures were within the prescribed temperature range of 22 to 24°C. - Reference substance:
- acetic acid, sodium salt
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 60
- Sampling time:
- 28 d
- Remarks on result:
- other: when inoculated with river water
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 53
- Sampling time:
- 28 d
- Remarks on result:
- other: when inoculated with activated sludge
- Details on results:
- Using active sludge as inoculums Cedryl Methyl Ether was biodegraded 53 and 61% at day 28 and 56, respectively. The biodegradability of Cedryl Methyl Ether was slightly better with river water. With river water 60% was achieved at day 28. This biodegradation percentage at day 28 allows classification as readily biodegradable. The 14-day time window should not be applied because this substance probably contains different stereoisomers. The test result clearly demonstrates that Cedryl Methyl Ether is not persistent.
- Validity criteria fulfilled:
- yes
- Remarks:
- See 'Any other information on materials and methods incl. tables',
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The substance showed 60% biodegradation river water in an OECD TG 301D test.
- Executive summary:
The ready biodegradability of Cedramber was investigated in a study conducted in accordance with OECD TG 301D (Closed Bottle Test). The concentration tested was 2 mg/l test substance. The biodegradability of the substance was with river water 60% at day 28. This biodegradation percentage at day 28 allows classification as readily biodegradable. The 14 -day time window should not be applied because this substance contains many small impurities. A slight inhibition of the endogenous respiration of the microorganisms present in river water at day 7 by the test substance was detected.
Reference
Table: Percentages biodegradation of Cedryl Methyl Ether (BOD/ThOD) in the Closed Bottle test.
Time (days) |
Biodegradation (%) |
|
Activated sludge |
River water |
|
0 |
- |
- |
7 |
16 |
-2 (toxic) |
14 |
34 |
38 |
21 |
48 |
49 |
28 |
53 |
60 |
42 |
58 |
66 |
56 |
61 |
- |
Description of key information
The ready biodegradability of Cedramber was investigated in a study conducted in accordance with OECD TG 301D (Closed Bottle Test). The concentration tested was 2 mg/l test substance. The biodegradability of the substance was with river water 60% at day 28. This biodegradation percentage at day 28 allows classification as readily biodegradable. The 14 -day time window should not be applied because this substance contains many small impurities. A slight inhibition of the endogenous respiration of the microorganisms present in river water at day 7 by the test substance was detected.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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