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Diss Factsheets
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EC number: 810-703-1 | CAS number: 1187441-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- Toxicokinetic assessment of the substance based on the available data
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: since this is a theoretical assessment, the Klimisch value cannot be 1.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
- Objective of study:
- other: Toxicokinetic assessment of the substance based on the available data
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance for the implementation of REACH. Guidance on information requirements and chemical safety assessment. Chapter R.7c: Endpoint specific guidance. European Chemical Agency.
- Version / remarks:
- Version 2.0; November 2014
- Deviations:
- not applicable
- GLP compliance:
- no
Results and discussion
Any other information on results incl. tables
Toxicokinetic assessment
A toxicant can enter the body via the gastrointestinal tract, the lungs and the skin.
In general, a compound needs to be dissolved before it can be taken up from the gastrointestinal tract after oral administration. POEMA is good water soluble and, in combination with the partition coefficient (≤ 3.6), the absorption of POEMA is considered to be good. For risk assessment purposes oral absorption of POEMA is set at 100%. The oral toxicity data do not provide reasons to deviate from the proposed oral absorption factor.
For inhaled substances the processes of deposition of the substance on the surface of the respiratory tract and the actual absorption have to be differentiated. A vapor pressure of less than 0.5 kPa (< 1.5 × 10-3 Pa) and a boiling point above 150°C (reaction and/or decomposition of the test substance was observed starting at 175°C) indicate a low volatility. If POEMA reaches the tracheobronchial region, it is likely to diffuse/dissolve into the mucus lining of the respiratory tract due to its water solubility and subsequently will be absorbed due to its partition coefficient.
Based on the above data, for risk assessment purposes the inhalation absorption of POEMA is set at 100%. The oral toxicity data do not provide reasons to deviate from the proposed inhaled absorption factor.
POEMA is a liquid which is taken up when it comes in contact with the skin. According to the criteria given in the REACH Guidance, a default value of 100% dermal absorption should be used unless MW >500 and log Pow <-1 or >4, in which case a value of 10% skin absorption should be chosen. The log Pow of POEMA indicates that absorption is to be expected. In addition, POEMA has skin corrosive properties, resulting in destruction of the skin barrier function. Based on these considerations, for risk assessment purposes the dermal absorption of POEMA is set at 100%.
Once absorbed, distribution of the substance throughout the body is expected based on its water solubility and partition coefficient. Absorbed POEMA might undergo biotransformation. The biotransformation products will either be excreted via the bile (high molecular weight compounds) or excreted via urine (low molecular weight compounds). Based on its partition coefficient and water solubility POEMA is not expected to accumulate significantly in adipose tissue.
Applicant's summary and conclusion
- Conclusions:
- For risk assessment purposes, 100% is used for oral, dermal and inhalation absorption.
Based on the available information POEMA is considered to have no significant bioaccumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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