Registration Dossier
Registration Dossier
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EC number: 218-250-6 | CAS number: 2093-20-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- The test substance is chemically very similar to the substance in this registration. Together with information from the ethylene glycol monoacetate, which is classified with H318 (ECHA CLP-register), and other monoacetates of glycol ethers the basis is sufficient for a risk assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Chemical Burns of the Rabbit Cornea
- Author:
- Charles P. Carpenter, Henry F. Smyth Jr.
- Year:
- 1 946
- Bibliographic source:
- American Journal of Ophthalmology 29, 1363, 1946
- Reference Type:
- secondary source
- Title:
- No data
- Author:
- No data
- Year:
- 2 016
- Bibliographic source:
- RTECS-Database 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Pre-Guideline and Pre-GLP-Study
- GLP compliance:
- no
Test material
- Reference substance name:
- Oxydiethylene di(acetate)
- EC Number:
- 211-049-4
- EC Name:
- Oxydiethylene di(acetate)
- Cas Number:
- 628-68-2
- Molecular formula:
- C8H14O5
- IUPAC Name:
- 2-(2-acetyloxyethoxy)ethyl acetate
- Details on test material:
- see literature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Results and discussion
In vivo
Results
- Remarks on result:
- other: Moderate irritation potential. Old study resp. database, no details on results
Any other information on results incl. tables
On application of 500 mg of the substance into the eye of a rabbit a moderate irritation was observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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