Titanium tetrakis(2-ethylhexanolate)

Endpoint summary

Description of key information

No data are available for for Tetraethylhexyl titanate itself. Rapid hydrolyses into 2 -Ethyl hexanol and Titanium dioxide is expected after ingestion into the body.

2-Ethyl hexanol is rapidly and extensively absorbed via the gastrointestinal tract in rats and rabbit.

2 -Ethylhexanol was evaluated in OECD SID Programme in 1995. Only short summary of the conclusions and reccomendations is available:

Repeat dose 90-day toxicity studies have been performed (via the oral route (rat, mouse), inhalation route (rat)). Effects on the liver, stomach, and kidney degeneration were reported. For oral exposure NOAEL is 125mg/kg/d (rat), inhalation NOAEL is ≥0.639mg/l/d. For dermal route subacute studies are available and the NOAEL is < 1.66 g/kg/d.

Repeated dose oral toxicity of titanium dioxide has been investigated in two studies. In a study following OECD TG 407, the test substance was administered via gavage to 5 rats/sex/dose at 0 (vehicle control, 1% methyl cellulose solution), 250, 500 or 1,000 mg/kg bw/day for 28 days. Additional recovery groups of 5 animals/sex were included in the control and high dose groups and observed for 14 days after treatment. No deaths were observed in either sex. Treatment related effects observed (compound-colored feces, effects on a few functional performance tests, some hematological and clinical chemistry parameters, liver and thymus weight changes) were not considered to be toxicologically significant. Therefore, the NOAEL was considered to be 1,000 mg/kg bw/day. In another study conducted according to OECD TG 407, titanium dioxide was administered via gavage to 5 male rats/dose at 0 or 24,000 mg/kg bw/day for 28 days. No substance related effects were observed and the NOAEL was considered to be 24,000 mg/kg bw/day.