Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across from an analogue substance for which a guideline study (Klimish 1) is available.
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across approach from data on an analogue substance.
- Specific details on test material used for the study:
- See attached document.
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 124.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Based on a read-across from an analogue subtance.
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 32.4 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Based on a read-across from an analogue subtance.
- Details on results:
- Based on experimental results on analogue substance P0310 where 72h-NOEC was 100 mg/L based on growth rate (mean measured concentration of 26 mg/L), the read-across approach is applied and the 72h-NOEC for substance P-1057 is calculated to be ≥ 124.5 mg/L (32.4 mg/L measured concentration).
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from analogue substance P0310, the NOEC (72h) of the substance P-1057 is calculated to be ≥ 124.5 mg/L (32.4 mg/L measured concentration).
- Executive summary:
Based on experimental results on analogue substance P0310 where 72h-NOEC was 100 mg/L based on growth rate (mean measured concentration of 26 mg/L), the read-across approach is applied and the 72h-NOEC for substance P-1057 is calculated to be ≥ 124.5 mg/L (32.4 mg/L measured concentration).
Reference
Description of key information
Key study: Based on read-across approach from analogue substance P0310, the NOEC (72h) of the substance P-1057 is calculated to be ≥124.5 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 124.5 mg/L
Additional information
Key study: Based on experimental results obtained in a study according to OECD 201 on analogue substance P0310 where 72h-NOEC for algae was determined to be>100 mg/L (based on growth rate), the read-across approach is applied and the 72h-NOEC for substance P-1057 is determined to be ≥124.5 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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