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EC number: 445-620-6 | CAS number: 39318-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22/05/2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study has been performed according to OECD and EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Directive 67/548 amended November 18, 1987 (87/302), Part C: Methods for the determination of ecotoxicity, Publication No. L133, "Biodegradation: Activated sludge respiration inhibition test", adopted May 30, 1988.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes
Test material
- Reference substance name:
- Terraces L
- IUPAC Name:
- Terraces L
- Reference substance name:
- Lithium Potassium Titanium Oxide
- EC Number:
- 445-620-6
- Cas Number:
- 39318-30-4
- Molecular formula:
- Hill Empirical formula: K(0.5-0.7) Li(0.27) Ti(1.73) O(3.8-3.95) CAS Empirical formula: K(0.5-0.7) Li(0.27) Ti(1.73) O(3.8-3.95)
- IUPAC Name:
- Lithium Potassium Titanium Oxide
- Details on test material:
- - Name of test material (as cited in study report): Terraces L
- Substance type: White powder
- Physical state: solid
- Analytical purity: 100 %
- Lot/batch No.: 2D79A
- Storage condition of test material: At room temperature in the dark
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- not required
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The synthetic sewage feed (16 ml) and an adequate amount of the test substance (49.6 mg) were mixed and made up to 300 ml with Milli-RO water. Activated sludge (200 ml) was added and the mixture was aerated in a 1 l bottle during the contact time, using a pipette as an aeration device. The flasks were filled up to 500 ml final volume. The final concentration was 100 mg/L. The test substance was tested in duplicate. Additionally, a control without test substance was included in duplicate. The reference substance was tested in triplicate.
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- The sludge was coarsely sieved and washed with tap-water. After concentration a small amount of the sludge was weighed and dried at ca. 105°C to determine the amount of suspended solids (3.1 g/l of sludge, as used for the test). Before use the pH was checked (measured value: 7.6).
The batch of sludge was used on the subsequent day, therefore 50 ml of synthetic sewage feed was added to each litre of activated sludge at the end of the day. The sludge was kept aerated at test temperature until use.
Study design
- Test type:
- other: aerobic
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 0.5 h
- Post exposure observation period:
- the contents was poured into a 300 ml oxygen bottle, and the flask was sealed with an oxygen electrode connected to a recorder, forcing the air out of the vessel. Oxygen consumption was measured and recorded for approximately 10 minutes. During measurement, the sample was not aerated but continuously stirred on a magnetic stirrer. The pH was determined in the remaining part of the reaction mixture.
Test conditions
- Test temperature:
- 20.2-20.5°C
- pH:
- 8.0-8.1
- Dissolved oxygen:
- 7.8-7.9 mg/L at the start of the test
- Nominal and measured concentrations:
- nominal 100 mg/L. No measured concentrations
- Details on test conditions:
- TEST SYSTEM
- Test vessel: All glass, 300 ml oxygen bottles and 1 l test bottles
- Aeration: continuous; clean, oil free air.
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Tap-water purified by reverse osmosis (Milli-RO) and subsequently passed over activated carbon and ion-exchange cartridges (Milli-Q) (Millipore Corp., Bedford, Mass., USA).
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Oxygen consumption was measured for approximately 10 minutes after the exposure period to determine the respiration rate. - Reference substance (positive control):
- yes
- Remarks:
- 3.5 dichlorophenol
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: loading rate
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 30 min
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: loading rate
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Relevant effect levels: The EC50 of 3,5-dichlorophenol was in the accepted range of 5-30 mg/l (17.6 mg/l, regression line: Y = 58.04 X –22.24, Y = % inhibition and X = log concentration (mg/l)).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of this present test, TERRACESS L was not toxic to waste water (activated sludge) bacteria at a concentration of 100 mg/l.
This concentration was prepared by direct addition of TERRACESS L to the test vessels and exceeded the solubility of TERRACESS L in water.
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