Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 436-900-9 | CAS number: 39290-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The acute oral toxicity of Terracess P is low, with
LD50> 2000 mg/kg body. The acute toxicity after inhalation is
also low (4h-LC50 > 5.04 g/m3). Therefore, an extensive
toxicokinetic assessment is considered of limited
value. Below, an assessment of the anticipated toxicokinetic
behaviour of Terracess P is given.
The water solubility of Terracess P is very low (<36
microg/l), and should be considered a rate-limiting factor for
the absorption of the compound from the gastro-intestinal
tract. Solubility might be increased by the low pH in the
stomach, which then may result in an increased absorption.
However, also uptake of the smaller particles may take
place by pinocytosis into intestinal cells. Mg2
+ is the second most plentiful cation of the intracellular fluids.
The average 70-kg adult has about 2000 mEq of Mg2+
in his body and the daily dietary intake is 0.25-0.50 g
daily. Approximately one third is absorbed from
the gastro-intestinal tract. Chronic ingestion of Mg2 +
causes only slight increases in plasma concentrations of Mg2+
in individuals with normal renal function.
Approximately 3 percent of an oral dose of titanium is absorbed.
The estimated body burden of titanium is about 15 mg. Most of it is in the lungs, probably as a result of inhalation exposure. Inhaled titanium remains in the lungs for long periods. It has been estimated that about one third of the inhaled titanium is retained in the lungs. Lung burdens tend to increase with age.
The potassium, magnesium and titanium ions are primarily excreted renally.
Dermal absorption of the compound is expected to be low.
The anticipated kinetic behaviour is supported by the acute and semichronic toxicity data. The observed effects after inhalation of Terracess P are probably caused by precipitation of the substance in the lungs.
Based on this and the RIVM Risk assessment as performed in 2008 (BMS080702.11), values taken for absorption are: 50% for oral, 10% for dermal and 100% for inhalation absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.