Registration Dossier
Registration Dossier
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EC number: 233-786-0 | CAS number: 10361-29-2
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Wilson RP et al
- Year:
- 1 968
- Bibliographic source:
- Am. J. Vet. Res., Vol. 29, No. 4, 897-906
Materials and methods
- Principles of method if other than guideline:
- no guideline followed
- Type of method:
- in vivo
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Commercial reagent grade ammonium carbonate was reported to be a mixture of ammonium carbamate and ammonium bicarbonate, or posiibly a double salt with the formula (NH4HCO3 x NH4CO2NH2). On exposure to air, commercial ammonium carbonate readily transformed to ammonium bicarbonate with the evolution of ammonia.
Constituent 1
Test animals
- Species:
- dog
- Strain:
- other: mongrel dog
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: 0.03 mM NaOH (pH 11)
- Details on exposure:
- 1 dog anesthezized by sodium pentobarbital solution (30 mg/kg bw)
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.25 mM / kg bw
Basis:
- No. of animals per sex per dose:
- 1 dog (sex not specified)
Examinations
- Examinations:
- sinus tachycardia, myocardial ischemia, ventricular tachycardia, ventricular flutter and death in ventricular fibrillation; changes in respiratory rate and convulsions
Results and discussion
- Details on results:
- sinus tachycardia, myocardial ischemia, ventricular tachycardia, ventricular flutter and death in ventricular fibrillation were observed; changes in respiratory rate and convulsions (no further data)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
