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EC number: 235-157-6 | CAS number: 12092-47-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a guideline skin irritation study, RH-93 chloro (cycloocta-1, 5-diene) rhodium (I) dimer (0.5 g) produced a primary irritation index of 0 following 4-hr semi-occluded application to the clipped, intact skin of three rabbits (Collier & Wilson, 1984).
No data were identified relating to irritation of the eyes or the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 June 1984 – 16 June 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to a protocol based on OECD guideline No. 404
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- The study was performed according to Safepharm Standard Protocol Number GM 04/82/40B which is based on OECD Guideline 404.
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Nottingham University, School of Agriculture, Sutton Bonington, Leics
- Age at study initiation: approx. 12-16 weeks
- Weight at study initiation: 2.75-3.01 kg
- Housing: individually in suspended metal cages
- Diet: ad libitum standard laboratory diet (Rabbit Diet, AW Tindall Ltd, Holbeach, Lincolnshire)
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 4
- Humidity (%): 70-75
- Air changes (per hr): 10 changes / hr
- Photoperiod (hrs dark / hrs light): 12 hr light/dark cycle - Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
- Amount(s) applied (volume or weight with unit): enough to moisten the test material
- Purity: sterile distilled water - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- Approx. 1hr following removal of the patches, and 24, 48 and 72 hrs later. If irritation persisted at the 72 hr-reading, a further observation was made 7 days following removal of the patches.
- Number of animals:
- 3 (sex unspecified)
- Details on study design:
- TEST SITE
- Area of exposure: not specified
- Type of wrap if used: The site of application was covered with 6.25 cm2 of surgical gauze two layers thick. This was secured in position with two lengths of Sleek adhesive strapping in the form of a cross and the trunk of the animal was wrapped in an elasticated corset to prevent access to the patch.
REMOVAL OF TEST SUBSTANCE
- Washing: yes – gentle swabbing with cotton wool soaked in lukewarm water.
- Time after start of exposure: 4 hrs
SCORING SYSTEM: The sites were scored according to Draize, 1959 – see below. A full description of any serious lesions, a description of the degree and nature of irritation, corrosion or reversibility, and any other toxic effects were made. The scores for erythema and oedema at the 24 and 72 hr readings were totalled for the three test animals and divided by 6 to give the Primary Cutaneous Irritation Index, which was used to classify the skin irritation properties according to:
Primary Irritation Index Classification
0 non-irritant
>0 - 2 mild irritant
>2 - 5 moderate irritant
>5 - 8 severe irritant - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hrs after removal of the patches
- Score:
- ca. 0
- Max. score:
- 8
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hrs after removal of the patches
- Score:
- ca. 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 hrs after removal of the patches
- Score:
- ca. 0
- Max. score:
- 4
- Irritant / corrosive response data:
- None of the rabbits showed any observable response to treatment throughout the 72-hr observation period.
- Other effects:
- None reported
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a guideline skin irritation study, RH-93 chloro (cycloocta-1, 5-diene) rhodium (I) dimer (0.5 g) produced a primary irritation index of 0 following 4-hr semi-occlusive application to the clipped, intact skin of three rabbits.
- Executive summary:
RH-93 chloro (cycloocta-1, 5-diene) rhodium (I) dimer (MS 400) (0.5 g) was applied (semi-occluded) to the clipped, intact skin of three New Zealand white rabbits (sex unspecified). After 4 hrs, the dressings were removed and the skin sites gently washed and assessed for erythema (and eschar) and oedema formation 1, 24, 48 and 72 hrs after removal of the patches. The values of the individual grades obtained from the skin areas at observation times 24 and 72 hrs were totalled and divided by 6 to give a primary irritation index of 0.0. No overt sings of toxicity were reported. RH-93 chloro (cycloocta-1, 5-diene) rhodium (I) dimer was considered as non-irritant in this test.
Based on the results of this study, no classification for skin irritation is required according to EU CLP criteria (EC 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant irritation/corrosion human data were identified.
RH-93 chloro (cycloocta-1, 5-diene) rhodium (I) dimer (MS 400) (0.5 g) was applied (semi-occluded) to the clipped, intact skin of three New Zealand white rabbits (sex unspecified). After 4 hrs, the dressings were removed and the skin sites gently washed and assessed for erythema (and eschar) and oedema formation 1, 24, 48 and 72 hrs after removal of the patches. The values of the individual grades obtained from the skin areas at observation times 24 and 72 hrs were totalled and divided by 6 to give a primary irritation index of 0.0. No overt sings of toxicity were reported. RH-93 chloro (cycloocta-1, 5-diene) rhodium (I) dimer was considered as non-irritant in this test (Collier & Wilson, 1984).
No data were identified relating to irritation of the eyes or the respiratory tract.
Justification for selection of skin irritation / corrosion endpoint:
OECD guideline study, and the only skin irritation study available.
Justification for classification or non-classification
Based on the results of the available and reliable skin irritation study in rabbits, di-μ-chloro-bis(hapto-1,5-cyclooctadiene)dirhodium(I) does not require classification for skin irritation according to EU CLP criteria (EC 1272/2008).
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