Registration Dossier
Registration Dossier
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EC number: 201-539-6 | CAS number: 84-54-8
Endpoint summary
Administrative data
Description of key information
Hydrolysis
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to undergoe > 5 days to 1.4 yrs at a pH range 4-9, respectively & at a temperature of 25⁰C. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.
Additional information
Hydrolysis
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 25°C and pH 4, 7 and 9, respectively. Although the exact half-life value of test chemical was not known, but was reported to be stable during a period of 5 days. Thus, the half-life value of test chemical can be determined to be > 5 days at a pH 4, 7 and 9 & at a temperature of25⁰C, respectively, indicating that the test chemical is not hydrolysable.
In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis the test chemical can be expected to undergoe > 5 days to 1.4 yrs at a pH range 4-9, respectively & at a temperature of 25⁰C. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.
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