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Diss Factsheets
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EC number: 229-319-5 | CAS number: 6471-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Low concern for repeated dose toxicity of 5-methoxy-2-methylsulphanilic acid based on read-across with similar substances.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Data from reliable sources (SIDS dossier of 4-aminotoluene-3-sulfonic acid and ECHA website for sulphanilic acid)
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data are available for repeated dose toxicity oral exposure of 5-methoxy-2-methylsulphanilic acid.
We can assume the absence of concern regarding repeated dose toxicity oral exposure of 5-methoxy-2-methylsulphanilic acid based on read-across with two compounds of similar structure(more similar substance: 4-aminotoluene-3-sulfonic acid; less similar substance: sulphanilic acid).For justification of read-across see attachment document in section 13.
As reported in SIDS Dossier of 4-aminotoluene-3-sulfonic acid approved at SIAM 16 (27 -30 May 2003) with reference to Ministry of Health & Welfare, Japan (1996): Toxicity Testing Reports of Environmental Chemicals, vol.4 p.99-106, "Twenty-eight-day Repeat Dose Oral Toxicity Test of 2-Amino-5-methylbenzenesulfonic acid in Rats" NOAEL for oral repeat dose toxicity to rats is 300 mg/kg/day. The substance was administered to each 6 male and 6 female Sprague-Dawley rats at doses of 0, 100, 300, 1000 mg/kg/day by gavage for 28 days. Toxicological effects were decrease of white blood cell count, total cholesterol and urine pH and enlargement of cecum in males at 1000 mg/kg/day; increase of GPT, decrease of glucose and enlargement of cecum in females at 1000 mg/kg/day.
From information published on ECHA website with reference to an experimental study of 2010 on rats for 28 days regarding sulphanilic acid the NOAEL was determined to be 1000 mg/kg bw for both sexes. The study was conducted according to OECD 407.
The public ECHA database contains data that are proprietary and cannot be used without the formal consent of the owner. In this summary, some of them have been used for precautionary purposes and for the benefit of the human health and the environment. Those data are not necessary for the registration of the target substance which is used exclusively as isolated and transported intermediate, but they can be very helpful for a better definition of the (eco) toxicological property of the substance. No other use and no commercial advantage will derive from the use of those data.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Read across with similar substances
Justification for classification or non-classification
According to CLP Regulation (EC n. 1272/2008), 5-methoxy-2-methylsulphanilic acid should be not classified for repeated dose toxicity: no data are available for the substance but from read-across with 4-aminotoluene-3-sulfonic acid and sulphanilic acid there is no reason of concern.
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