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EC number: 251-974-0 | CAS number: 34375-28-5
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
From Scifinder,Chemspider database and Using Bio-concentration Factor (v12.1.0.50374) module of ACD lab to determine Bio-concentration Factor over the entire pH scale 1-14 of the test substance 2-[hydroxy(methyl)amino]ethanol estimated to be 1 (dimentionless).This value indicates that the test substance2-[hydroxy(methyl)amino]ethanolfound to be non-accumulative in aquatic organisms.
Additional information
Bioaccumulation: aquatic / sediment
Three results including different predicted data from validated models for bioaccumulation (BCF) endpoint of target chemical 2-[hydroxy(methyl)amino]ethanol (Cas no. 34375-28-5) were summarized as follows:
First prediction done using ACD (Advanced Chemistry Development)/I-Lab; Algorithm Version: v5.0.0.184 using Bio-concentration Factor (v12.1.0.50374) module and also from Scifinder and chemspider database; 2017 indicate the bio-concentration Factor over the entire pH scale 1-14 of the test substance 2-[hydroxy(methyl)amino]ethanol estimated to be 1 (dimentionless).This value indicates that the test substance 2-[hydroxy(methyl)amino]ethanol found to be non-accumulative in aquatic organisms.
Another validated prediction by BCFBAF (v3.00) model and PBT profiler database indicate the estimated bio concentration factor (BCF) for 2-[hydroxy(methyl)amino]ethanol is 3.2 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that 2-[hydroxy(methyl)amino]ethanol is not expected to bio accumulate in the aquatic environment.
Above all predictions assist by result from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) indicate the bioaccumulation i.e BCF for test substance 2-[hydroxy(methyl)amino]ethanol was estimated to be 3.14 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance 2-[hydroxy(methyl)amino]ethanol non-bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
Thus based on the above information for bioaccumulation endpoint, it can be concluded that the test substance 2-[hydroxy(methyl)amino]ethanol (Cas no. 34375-28-5) is expected to be non Bioaccumulative in aquatic environment as none of the study indicate the 2-[hydroxy(methyl)amino]ethanol exceed the BCF threshold of 2000.
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