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EC number: 276-558-6 | CAS number: 72275-69-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- July 29, 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: "Hazardous Substances Regulations" under the U.S. Federal Hazardous. Substances Labelling Act Sect. 191.11 (February 1965).
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Similar substance 1
- IUPAC Name:
- Similar substance 1
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Porton
- Age at study initiation: aged 10-13 weeks
- Weight at study initiation: 2.73 Kgs (♂), 2.38 kgs (♀)
- Housing: caged singly
- Diet: A commercial irradiated diet (Styles-Oxoid) was fed ad libitum
- Water: Sterile filtered water ad libitum.
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1 °C
- Humidity (%): 50-70 %
- Photoperiod (hrs dark / hrs light): Animals were exposed to artificial light for 10 hours daily from 08.00 - 18.00 hours.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved and abraded
- Vehicle:
- other: water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
10g. of the test compound was mixed with 12 ml. of water to make a solution of 15ml. 0.75ml of which was applied to each test site on a 2.5 cm. square gauze pad. - Duration of treatment / exposure:
- The gauze patches were removed 24 hours after the application.
- Observation period:
- The reaction of the skin was appraised upon removal and 72 hours after it.
- Number of animals:
- 3 males/3 females
- Details on study design:
- TEST SITE
- Area of exposure: Two test sites lateral to the mid line of the back were used on each rabbit
- % coverage: 10 % of the total body surface.
- Type of wrap if used: 0.75ml of test compound was applied to each test site on a 2.5 cm. square gauze pad. These were covered with aluminium foil secured with "Sleek"* adhesive tape. The test sites were then enclosed by a 6" wide "Coban" self adhesive bandage the edges of which were fixed to the skin strips of "Sleek" in order to retain the test substance in close contact with the skin.
SCORING SYSTEM: Draize et al.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 11, 13, 15, 12, 16
- Time point:
- other: 24, 48, 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal: 14
- Time point:
- other: 24, 48, 72 hours
- Score:
- ca. 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal: 11
- Time point:
- other: 24, 48, 72 hours
- Score:
- ca. 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal: 12
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal: 13
- Time point:
- other: 24, 48, 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal: 14
- Time point:
- other: 24, 48, 72 hours
- Score:
- ca. 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal: 15
- Time point:
- other: 24, 48, 72 hours
- Score:
- ca. 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal: 16
- Time point:
- other: 24, 48, 72 hours
- Score:
- ca. 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible
Any other information on results incl. tables
Slight erythema and very slight to moderate oedema was seen on 2/6 and 5/5 rabbits respectively, 24 hours after application of the compound. All sites were normal by 72 hours.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- According to the CLP Regulation (EC n. 1272/2008)
- Conclusions:
- The substance is not irritating for skin rabbit.
- Executive summary:
The substance has been tested for skin irritation/corrosion according to The guideline "Hazardous Substances Regulations" under the U.S. Federal Hazardous. Substances Labelling Act Sect. 191.11 (February 1965). 6 Healthy New Zealand White rabbits (3 males and 3 females) were acclimatized in the test area for one week prior to the start of the trial. Twenty-four hours prior to the dermal application, the backs of the rabbits were shaved over an area consisting of at least 10% of the total body surface. Immediately before the application of the test compound, the right hand site was abraded with the point of a sterile hypodermic needle. 10g of the test compound was mixed with 12 ml of water to make a
solution of 15 ml. 0.75ml of which was applied to each test site on a 2.5 cm square gauze pad.
Slight erythema and very slight to moderate oedema was seen on 2/6 and 5/5 rabbits respectively, 24 hours after application of the compound. All sites were normal by 72 hours. There was no marked difference in the reactions between abraded and intact sites.. The substance is not irritating for skin rabbit according to the CLP Regulation (EC n. 1272/2008).
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