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EC number: 212-480-0 | CAS number: 821-55-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
LD50 was considered t be > 5000 mg/kg bw when rats were treated with nonan-2-one orally.
Acute dermal toxicity:
LD50 was considered t be > 5000 mg/kg bw when rabbits were treated with nonan-2-one by dermal application.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviwed journal
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- Acute oral toxicity study of nonan-2-one in rats
- GLP compliance:
- no
- Test type:
- other: No data
- Limit test:
- yes
- Specific details on test material used for the study:
- - Name of test material: 2-Nonanone (nonan-2-one )
- IUPAC name: nonan-2 -one
- Molecular formula: C9H18O
- Molecular weight: 142.24g/mol
- Substance type: Organic
- Physical state: No data
- Purity: No data available
- Impurities (identity and concentrations): No data - Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Preliminary study:
- No data
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No 50% mortality observed
- Mortality:
- Death of one out of ten rats was observed at 5000 mg/kg bw
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- not classified
- Conclusions:
- LD50 was considered t be > 5000 mg/kg bw when rats were treated with nonan-2-one orally.
- Executive summary:
In a acute oral toxicity study, 10 rats were treated with nonan-2-one in the concentration of 5000 mg/kg bw orally. Death of one out of ten rats was observed at 5000 mg/kg bw. Therefore, LD50 was considered t be > 5000 mg/kg bw when rats were treated with nonan-2-one orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer- reviewed journal
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer -reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- Acute dermal toxicity study of nonan-2-one in rabbits
- GLP compliance:
- no
- Test type:
- other: No data
- Limit test:
- yes
- Specific details on test material used for the study:
- - Name of test material: 2-Nonanone (nonan-2-one )
- IUPAC name: nonan-2 -one
- Molecular formula: C9H18O
- Molecular weight: 142.24g/mol
- Substance type: Organic
- Physical state: No data
- Purity: No data available
- Impurities (identity and concentrations): No data - Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- 24 hour
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 7
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: no data
- Frequency of observations and weighing:no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: mortality, clinical signs and gross pathology were observed. - Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed in all seven animals.
- Mortality:
- No mortality was observed in all seven animals.
- Clinical signs:
- Irritation was observed in treated rabbits at 5000 mg/kg bw
- Body weight:
- No data available
- Gross pathology:
- scaly skin was observed in treated rabbits at 5000 mg/kg bw
- Other findings:
- No data available
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered t be > 5000 mg/kg bw when rabbits were treated with nonan-2-one by dermal application.
- Executive summary:
In a acute oral toxicity study, 7 rabbits were treated with nonan-2-one in the concentration of 5000 mg/kg bw orally. No mortality were observed in treated rabbits at 5000 mg/kg bw. Irritation and scaly skin was observed in treated rabbits at 5000 mg/kg bw. Therefore, LD50 was considered t be > 5000 mg/kg bw when rabbits were treated with nonan-2-one by dermal application.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer- reviewed journal
Additional information
Acute oral toxicity:
In different studies, nonan-2-one has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in mice and rats for nonan-2-one. The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In a study conducted by Morenoet al(Food and Chemical Toxicology Volume 26, Issue 4, 1988, Pages 393), 10 rats by using nonan-2-one in the concentration of 5000 mg/kg bw orally. Death of one out of ten rats was observed at 5000 mg/kg bw. Therefore, LD50 was considered t be > 5000 mg/kg bw when rats were treated with nonan-2-one orally.
In another prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for nonan-2-one. LD50 value was estimated to be 4050 mg/kg bw when Wistar male and female rats orally treated with nonan-2-one.
Also it is further supported with prediction done by using Danish EPA Model, LD50 was estimated to be 5300 mg/kg bw when mice were treated nonan-2-one orally.
In addition study given by HPV Challenge Program (2007), acute oral toxicity was evaluated in 4 ddY male mice by using nonan-2-one in four concentrations orally by gavage in olive oil. Mice were pre-treated with an intraperitoneal injection of olive oil. 50 % mortality observed at 7879 mg/kg bw. Therefore, LD50 was considered to be 7879 mg/kg bw (5538-9552 mg/kg) when 4 ddY male mice were treated nonan-2-one in Olive Oil orally by gavage.
Thus, based on the above studies and predictions on nonan-2-one, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus comparing this value with the criteria of CLP regulation, 4-methylphenyl acetate can be “Not classified” for acute oral toxicity.
Acute dermal toxicity: New
In different studies, nonan-2-one has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rabbits for nonan-2-one along with the study available on structurally similar read across substance 2-Undecanone (CAS no: 112-12-9) and 6-Methyl-2-heptanone (CAS no: 928-68-7). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In an acute oral toxicity study by Morenoet al(Food and Chemical Toxicology Volume 26, Issue 4, 1988, Pages 393), 7 rabbits by using nonan-2-one in the concentration of 5000 mg/kg bw orally. No mortality were observed in treated rabbits at 5000 mg/kg bw. Irritation and scaly skin was observed in treated rabbits at 5000 mg/kg bw. Therefore, LD50 was considered t be > 5000 mg/kg bw when rabbits were treated with nonan-2-one by dermal application.
In another prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for nonan-2-one. LD50 value was estimated to be 5012 mg/kg bw for New Zealand White male and female rabbits.
Also it is further supported study given by HPV Challenge Program (2007) on structurally similar the read across substance 2-Undecanonein (CAS no: 112-12-9), 4 rabbits were treated with 2-Undecanone in the concentration of 5000 mg/kg bw by dermal application. No mortality was observed in treated rabbits at 5000mg/kg bw. Therefore, LD50 was considered to be >5000mg/kg bwwhen rabbits were2-Undecanoneby dermal application.
In above similar source study given for another structurally similar read across substance 6-Methyl-2-heptanone (CAS no: 928-68-7), 6 rabbits were treated with 6-Methyl-2-heptanone in the concentration of 5000 mg/kg bw by dermal application. One animal died on day 9. Therefore, LD50 was considered to be >5000 mg/kg bw when 6 rabbits were 6-Methyl-2-heptanone by dermal application.
Thus, based on the above studies and predictions on nonan-2-one and its read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, nonan-2-one can be “Not classified” for acute dermal toxicity.
Justification for classification or non-classification
Based on the above studies and predictions on nonan-2-one and its read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, nonan-2-one can be “Not classified” for acute oral and dermal toxicity.
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