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EC number: 250-333-2 | CAS number: 30772-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 May 1991 - 21 May 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliability 1 is assigned because the study conducted according to OECD TG 404 and in compliance with GLP, without deviations that influence the quality of the results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- (1981)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Octahydro-4,7-methano-1H-indenecarbaldehyde
- EC Number:
- 250-333-2
- EC Name:
- Octahydro-4,7-methano-1H-indenecarbaldehyde
- Cas Number:
- 30772-79-3
- Molecular formula:
- C11H16O
- IUPAC Name:
- (1R,2S,3S,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-3-carbaldehyde; bis((1R,2S,4R,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-4-carbaldehyde)
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Formyltricyclodecan
- Storage condition of test material: at ambient air temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- - Source: Harald Schriever, Kaninchenfarm, Neuendamm 88, D-2740 Bremervörde
- Weight at study initiation: 2-3 kg
- Housing: Individual housing
- Diet: ad libitum, pellets
- Water: ad libitum, tap water
ENVIRONMENTAL CONDITIONS:
- Temperature (°C): 20±3°C
- Humidity (%): 30-70%
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: contralateral eye of test animals
- Amount / concentration applied:
- TEST MATERIAL
Amount applied (volume): 0.1 mL - Duration of treatment / exposure:
- Single exposure
- Observation period (in vivo):
- 5 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- TREATMENT
The test substance was introduced into the conjunctival sac of the left eye of each animal.
REMOVAL OF TEST SUBSTANCE
- Washing: no
OBSERVATIONS
The eyes of each animal were assessed for ocular reactions 1, 24, 48 and 72 hours after treatment and thereafter once daily up to day 5. Irritation scores and a description of all other (local) effects were recorded.
SCORING SYSTEM
The irritation was assessed according to OECD 405 (1981).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- cornea opacity score
- Remarks:
- (opacity)
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hrs (mean)
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritant / corrosive response data:
- Slight ocular secretion was observed in all animals 1 hour after treatment. In one animal slight alteration of the iris occurred after 1 hour of initiation. Up to 3 days after treatment redness and chemosis of the conjunctivae were observed in all animals. The effects were fully reversible within 4 days.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an eye irritation study with rabbits, performed according to OECD 405, the mean cornea, iris, conjunctivae redness and conjunctivae chemosis scores for all animals were below the limits mentioned in the EU classification criteria. Based on these results, the substance is not considered to be irritating to the eye.
- Executive summary:
The substance was tested in an eye irritation test in 3 rabbits in accordance with OECD TG 405 test guideline. Slight ocular secretion was observed in all animals 1 hour after treatment. In one animal slight alteration of the iris occurred after 1 hour of initiation. Up to 3 days after treatment redness and chemosis of the conjunctivae were observed in all animals. The effects were fully reversible within 4 days. The mean cornea, iris, conjunctivae redness and conjunctivae chemosis scores of the 24, 48 and 72 hours reading for all animals were below the limits mentioned in the EU classification criteria (limits being 1, 1, 2 and 2, respectively). Based on these results, the substance is not considered to be irritating to the eye.
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