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Diss Factsheets
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EC number: 943-533-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of 6-ethyl-3-methyloct-5-en-1-ol and 6-ethyl-3-methyloct-6-en-1-ol
- Molecular formula:
- C11H22O
- IUPAC Name:
- Reaction mass of 6-ethyl-3-methyloct-5-en-1-ol and 6-ethyl-3-methyloct-6-en-1-ol
- Test material form:
- other: liquid
- Details on test material:
- Identification: Super Muguet
Batch Number: SC00011682
CAS Number: 26330-64-3
EC Number: 247-615-2 + 247-616-8
Molecular Formula: C11H22O
Molecular Weight: 170.30 g/mol
Expiration Date: 20 June 2016
Description: Clear, colourless liquid
Purity: 98.27 %
Storage Conditions: Sealed container, 15 - 30 °C, in the dark
Constituent 1
Test animals / tissue source
- Species:
- other: bovine
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Corneas taken from bovine eyes obtained from a local abattoir. The eyes were removeed after slaughter, completely immersed in Hanks' Balanced Salkt Solution in a suitably sized container and transported on the same day to the testing facility. On arrival at the test facility the eyes were carefully examined for defects including increased opacity, scratches and neovascularisation. Only conreas free from such defects were used.
The corneas were then excised from the eyes and loaded onto the specifically designed holders. Both chambers of each holder were filled with pre-warmed Minimal Medium (MEM), with the posterior chamber filled first, ensuring that no bubbles were formed. The holders were incubated at 32 °C +/- 1 °C for 1 hours. After the incubation, the media was removed from both the anterior and posterior chambers. Fresh media was added to the posterior chamber first and then the anterior chamber (this media replacement order ensured the cornea retained its hatural curvature as much as possibleP. The opacity of each cornea was measured using an opacitometer.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The negative control substance was 0.9% sodium chloride solution and the positive control substance was dimethyl formamide
- Amount / concentration applied:
- A volume of 750 µL of the test material was applied to each of the three corneas
- Duration of treatment / exposure:
- The corneas were incubated for 10 minutes at 32 °C after the test material was applied. After this incubation, each cornea was washed with media containing phenol red until this indicator showed no pH effect occuring. The corneas were then washed once in media without phenol red and the opacities were measured.
- Number of animals or in vitro replicates:
- 3 corneas
- Details on study design:
- Fresh corneas, mounted onto specifically designed holders were treated topically with the test material. Eye corrosion/severe irritation potential was based on the combined effect of the test article on the opacity of the cornea following the treatment and the cornea's ability to resist penetration of a fluorescent dye through the tissue.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corrected opacity
- Basis:
- mean
- Time point:
- other: NA
- Score:
- 21.7
- Irritation parameter:
- other: optical density
- Basis:
- mean
- Time point:
- other: NA
- Score:
- 0.516
- Irritation parameter:
- other: IVIS
- Time point:
- other: NA
- Score:
- 29.4
- Remarks on result:
- other: IVIS = mean opacity value + (15 x mean permeability value)
Applicant's summary and conclusion
- Interpretation of results:
- Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The test article, Super Muguet, produced an IVIS score of 29.40. The assay was considered valid as the assay acceptance criteria were met.
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