Registration Dossier
Registration Dossier
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EC number: 235-117-8 | CAS number: 12069-94-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference in foreign language (Russian).
Data source
Reference
- Reference Type:
- publication
- Title:
- Information of the Soviet Toxicological Center - Toxicity and hazard of niobium oxide (V)
- Author:
- Davidova V. I.
- Year:
- 1 991
- Bibliographic source:
- Gigiena Truda i Professional`nye Zabolevaniya 35(4):38
Materials and methods
- GLP compliance:
- not specified
- Test type:
- other: acute oral toxicity
Test material
- Reference substance name:
- niobium pentoxide
- IUPAC Name:
- niobium pentoxide
- Reference substance name:
- Diniobium pentaoxide
- EC Number:
- 215-213-6
- EC Name:
- Diniobium pentaoxide
- Cas Number:
- 1313-96-8
- Molecular formula:
- Nb2O5
- IUPAC Name:
- diniobium pentaoxide
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute toxicity study rats were administered orally with niobium pentoxide. The oral LD50 exceeds 10000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study published by Davidova, 1991, rats were orally treated with niobium pentoxide. The LD50 value was presented to be greater than 10000 mg/kg bw. Based on comparable low solubility, niobium pentoxide is considered a suitable read across partner for niobium carbide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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