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Diss Factsheets
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EC number: 281-506-0 | CAS number: 83968-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- DPIM: DQF800
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials):- Gigiena i Sanitariya. 34(3) (1969), 7.
- Reference Type:
- review article or handbook
- Title:
- DOSE No.: D394
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE):- Markosyan, T. M. Gig. Sanit. 1969, 34, 7-11.
- Reference Type:
- publication
- Title:
- Comparative toxicity of monomethyl-aniline and dimethyl-aniline in chronic experimental exposure.
- Author:
- Markosyan, T.M.
- Year:
- 1 969
- Bibliographic source:
- Gigiena i Sanitariya. 34(3)7-11. (Russian).
- Reference Type:
- other: Authoritative data base
- Title:
- CESARS Record no.:209
- Author:
- CESARS Database
- Year:
- 2 011
- Bibliographic source:
- CESARS (Chemical Evaluation Search and Retrieval System ); Markosyan, T.M. 1969. Comparative toxicity of monomethyl-aniline and dimethyl-aniline in chronic experimental exposure. Gig. Sanit.34(3)7-11. (Russ.). From CAS:71:11369.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Study obtained from Sax's Handbook of Dangerous Industrial Materials and Dictionary of Substances and their effects
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N-dimethylaniline
- EC Number:
- 204-493-5
- EC Name:
- N,N-dimethylaniline
- Cas Number:
- 121-69-7
- Molecular formula:
- C8H11N
- IUPAC Name:
- N,N-dimethylaniline
- Details on test material:
- - Name of test material (as cited in study report): N,N-dimethylaniline
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 100 days
- Frequency of treatment:
- 24 hr/day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.3 mg/m³
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Results of examinations
- Details on results:
- Rats showed significant changes in the central nervous system, blood and liver in the correlation of muscle antagonist chronaxy, a reduced number of erythrocytes and hemaglobin, increased methemoglobin level, reticulocytis, leukopenia, hypoproteinemia, a reduced-SH group content in the serum, and accumulation of pyruvic acid in the liver and serum. Dimethylaniline also increased the coproporphyrin urinary excretion and reduced the adrenal ascorbic acid level.
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- 0.3 mg/m³ air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: lowest observed advser effect
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The Lowest observed adverse effect concentration (LOAEC) of N,N-dimethylaniline was found to be 0.3 mg/m³ rats in a 100 day study.
Inhalation of the substance continuously led to anaemia, methaemoglobinaemia, leucopenia and significant pathological changes in the central nervous system. - Executive summary:
Repeated dose inhalation toxicit study was performed using rats for the test compound N, N- dimethylaniline (RA CAS no 121 -69 -7). The Lowest observed adverse effect concentration (LOAEC) of N,N-dimethylaniline was found to be 0.3 mg/m³ rats in a 100 day study. Inhalation of the substance continuously led to anaemia, methaemoglobinaemia, leucopenia and significant pathological changes in the central nervous system.
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