Registration Dossier
Registration Dossier
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EC number: 219-210-0 | CAS number: 2387-03-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from BASF study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: given below
- Principles of method if other than guideline:
- The objective was to assess the potential for eye irritation of the test material Lumogen LT light yellow to the mucous membrane of rabbit eye.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
- EC Number:
- 219-210-0
- EC Name:
- 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone
- Cas Number:
- 2387-03-3
- Molecular formula:
- C22H16N2O2
- IUPAC Name:
- 1,1'-(hydrazine-1,2-diylidenedimethylylidene)di(2-naphthol)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report):Lumogen LT light yellow (chemical name: 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone, CAS No 2387-03-3)- Molecular formula (if other than submission substance):C22H16N202- Molecular weight (if other than submission substance):340,385g/mol- Smiles notation (if other than submission substance):Oc1c(c2c(cccc2)cc1)\C=N\N=C\c1c2c(cccc2)ccc1O- InChl (if other than submission substance):1S/C22H16N2O2/c25-21-11-9-15-5-1-3-7-17(15)19(21)13-23-24-14-20-18-8-4-2-6-16(18)10-12-22(20)26/h1-14,25-26H/b23-13+,24-14+- Substance type:Organic- Physical state:Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No details available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 50 mg
- Duration of treatment / exposure:
- 24 hrs.
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- No data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 hr
- Reversibility:
- not specified
- Remarks on result:
- other: no irritation observed
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hrs.
- Reversibility:
- not specified
- Remarks on result:
- other: no irritation observed
Any other information on results incl. tables
Eye irritation (Rabbit) | Finding after 1 hrs. | Finding after 24 hrs. | Finding after 8 days |
Application of test material (50 mg) Unchanged | Slightly irritating | Slightly irritating | Not irritating |
Comparison substance:Talcum | Slightly irritating | Slightly irritating | Not irritating |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Test substance Lumogen LT light yellow (chemical name: 2-hydroxynaphthalene-1-carbaldehyde [(2-hydroxy-1-naphthyl)methylene]hydrazone, CAS No 2387-03-3) was found to be not irritating to the eye of rabbit after 8 days observation period.
- Executive summary:
When test substance Lumogen LT light yellow at dose concentration of 50 mg applied to the rabbit eyes showed slightly irritation during the exposure period of 1 hr. to 24 hrs.
After 8 days of observation period mucous membrane irritation of the test material on the eye is not stronger than that of the comparison product Talcum.
Thus from overall experimental result it is concluded that the test substance Lumogen LT light yellow consider to be not irritating to the eye of rabbit.
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