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Diss Factsheets
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EC number: 930-776-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not conducted to GLP, standard observations not made. Focus is on haematology and effect of Mn in rats maintained on low-Fe diets.
Data source
Reference
- Reference Type:
- publication
- Title:
- Chronic manganese oxide ingestion in rats: hematological effects
- Author:
- Carter SD, Hein JF, Rehnberg GL and Laskey JW
- Year:
- 1 980
- Bibliographic source:
- J. Toxicol. Environ. Health, 6(1): 207-216
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The haematological effects of chronic Mn3O4 exposure during both prenatal and postnatal periods was determined. Data was obtained from the parental to F2 generations. Effects of exposure to Mn3O4 during Fe deficiency were determined by placing half of the animals of a low Fe diet and the other half on a normal diet.
STUDY 1: Rats (known to be at gestation day 1) were randomly assigned to 8 treatment groups. Treatment began on gestational day 2 and was continued in the F1 generation through 244 d of age. - GLP compliance:
- no
Test material
- Reference substance name:
- Silicomanganese manufacturing fumes dedusting solid residues
- EC Number:
- 930-776-4
- IUPAC Name:
- Silicomanganese manufacturing fumes dedusting solid residues
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Details on exposure:
- Mean particle diameter:
STUDY 1: 0.62 µm (range 0.1 - 2.8 µm), 80% of particles evaluated were <1 µm in diameter.
STUDY 2: 1.2 µm (range: 0.1-5.6 µm), 45% of total particles were <1µm in diameter. - Details on mating procedure:
- STUDY 1: Animals were received at day 1 of gestation.
STUDY 2: Animals were received when pregnant. - Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- STUDY 1: treatment continued from day 2 of gestation to day 224 of age (F1 generation)
Study 2: treatment continued through pregnancy to day 40 of age (F1 generation). - Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
400, 1100 and 3550 ppm Mn
Basis:
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Study 1:
Red Blood Cell count, Haematocrit and Mean cell volume values of animals maintained on normal Fe diets differed significantly from animals maintained on low-Fe diets.
Mortality: mortality rate was increased (>50%) in animals at the highest dose group (low-Fe), from birth to 40 d of age. Consequently all remaining animals in this group were killed at day 40. All blood values were significantly lower than the control animals on the low-Fe diet.
Haematocrit values in the low-Fe groups was depressed from 24 to 100 days of age. There were no evident Mn dose responses.
A strong correlation between dietary Fe levels and certain serum constituents was noted at both 100 and 200 days of age.
Bodyweights and food consumption: A significant dose-related decrease in bodyweight was seen at days 52 and 88. animals receiving the low-Fe diet consumed more food than the controls. This was not significant.
Study 2:
No significant Mn -related effects.
Applicant's summary and conclusion
- Conclusions:
- Low -Fe diet animals were more sensitive to Mn exposure.
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