Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-916-9 | CAS number: 3279-27-4
Endpoint summary
Administrative data
Description of key information
Additional information
Several reliable measured and modeled toxicity studies in fish, invertebrates, and algae have been conducted for o-tert-amylphenol and are included in this dossier. Additionally, reliable toxicity studies with fish, invertebrates, algae, and microorganisms with the structural analogues o-tert-butylphenol and o-sec-butylphenol have been included for supporting evidence.
The reliable (Klimisch 2) key study for short-term toxicity to fish, Sasol (2016), provides an estimated 96 hr LC50 of 2.16 mg/L for o-tert-amylphenol. Consequently this value will be taken as the short-term toxicity in fish endpoint for o-tert -amylphenol.
Sasol (2016) provided a reliable (Klimisch 2) study for o-tert-amylphenol using the QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program to estimate long-term toxicity to fish. Model results indicate a 30 day chronic value (the geometric mean of the NOEC and LOEC) to be 0.262 mg/L. As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value. Therefore, the calculated NOEC = 0.185 mg/L and consequently will be taken for the long-term toxicity to fish endpoint.
The reliable key study for short-term toxicity to aquatic invertebrates, Hermes (2015), provides an estimated 48 hr LC50 of 1.77 mg/L to daphnids for o-tert-amylphenol. Consequently this value will be taken as the short-term toxicity endpoint in aquatic invertebrates for o-tert -amylphenol.
Sasol (2016) provided a reliable (Klimisch 2) study for o-tert-amylphenol using the QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program to estimate long-term toxicity to daphnids. Model results indicate a 21 day chronic value (the geometric mean of the NOEC and LOEC) to be 0.240 mg/L. As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value. Therefore, the calculated NOEC = 0.170 mg/L and consequently will be taken for the long-term toxicity to aquatic invertebrates endpoint.
The reliable (Klimisch 2) key study for toxicity to aquatic algae, Sasol (2016), provides estimated 96 hr EC50 of 2.36 mg/L and 96 hr ChV of 0.930 mg/L to green algae for o-tert-amylphenol. As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value. Therefore, the calculated NOEC is 0.658 mg/L. Consequently these values will be taken as the toxicity in aquatic algae endpoint for o-tert-amylphenol.
Horton et al. (1991) conducted a reliable study on the toxicity of the analogue, o-sec-butylphenol, to activated sludge microorganisms following OECD 209 guidelines. Activated sludge microorganisms were exposed to a control and 10 mg/L of the test substance for 3 hrs. Oxygen consumption was measured to determine the 3 hr EC50 of > 10 mg/L. Consequently, this value will be taken to fulfill the toxicity to microorganisms endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
