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EC number: 943-242-0 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 203).
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity ofReaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimersto fish are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance neopentyl glycol dioleate (CAS 42222-50-4) was conducted. The source substance is representative to evaluate the short-term toxicity ofReaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimersto fish. Both substances are structurally very similar. The target substance is characterized as a diester of neopentylglycol esterified with mainly C18 unsaturated fatty acids. The main constituent of the source substance is the neopentyl glycol dioleate containing additional constituents of higher molecular weight. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13.
The study on the read-across substance neopentyl glycol dioleate (CAS 42222-50-4) was conducted according to ISO 7346-1 investigating the short-term toxicity to fish (Brachydanio rerio) (Gode, 2008). The fish were exposed to the nominal test concentrations of 100, 300, 1000, 3000 and 10000 mg/L for 96 h. The test solutions were prepared as water accommodated fractions (WAF). No blank control was used in the test. However, as no mortalities were observed at any of the test concentrations, it can be concluded that neopentyl glycol dioleate is not acutely toxic to fish at concentrations ≤ 10000 mg/L. An LC50 (96 h) > 10000 mg/L is reported.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the target substance Reaction products from the esterification of neopentylglycol with fatty acids, C16-18 (even numbered) and C18-unsatd. and fatty acids, C18-unsaturated, dimers will not exhibit short-term effects to fish up to the limit of water solubility.
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