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Diss Factsheets
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EC number: 236-400-9 | CAS number: 13351-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable and well documented publication, no GLP study, equivalent to guideline, only a 20 % mixture of the test substance was tested
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2-dimethyl-3-phenylpropanol
- EC Number:
- 236-400-9
- EC Name:
- 2,2-dimethyl-3-phenylpropanol
- Cas Number:
- 13351-61-6
- Molecular formula:
- C11H16O
- IUPAC Name:
- 2,2-dimethyl-3-phenylpropan-1-ol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.4 - 2.6 kg
- Housing: single cages
- Diet: Muemml Z, Plange
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20
- Humidity (%): 45-55
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- other: peanut oil
- Controls:
- other: right eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL of the 20 % pure test substance - Observation period (in vivo):
- 1, 2, 8 hours and 1, 2, 3, 4, 5, 6 and 7 days after application
- Number of animals or in vitro replicates:
- 6 rabbits
- Details on study design:
- SCORING SYSTEM: According to Draize et al.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48. 72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The eye irritation potential was determined in a study equivalent to OECD guideline 405. Cornea, Iris, conjunctiva and chemosis scores were 0. No eye irritation effects were observed.
- Executive summary:
In a study equivalent to OECD guideline 405 the eye irritation with 6 New Zealand rabbits was tested. The test item was applied in an amount of 0.1 mL. Only a 20 % mixture of the test substance was tested. The room temperature was kept constantly at 20 °C with the relative humidity verying between 45 and 55 %. The duration of lighting was 12 hours/day. The animals were observed over a period of 1, 2, 8 hours and 1, 2, 3, 4, 5,6 and 7 days after application. The right eye served as control. Eye irritation was evaluated according to the criteria of Draize et al.
The mean scores at 24, 48 and 72 h for all animals were as following:
Cornea: 0
Iris: 0
Conjunctivae: 0
Chemosis: 0
No eye irritation effects were observed.
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